Academic Journal
Inhibition of Alpha-Glucosidase by Synthetic Derivatives of Lupane, Oleanane, Ursane and Dammarane Triterpenoids
| العنوان: | Inhibition of Alpha-Glucosidase by Synthetic Derivatives of Lupane, Oleanane, Ursane and Dammarane Triterpenoids |
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| المؤلفون: | Khusnutdinova, El'mira F., Smirnova, Irina E., Giniyatullina, Gul'nara V., Medvedeva, Natal'ya I., Yamansarov, Emil Yu., Kazakov, Dmitri V., Kazakova, Oxana B., Linh, Pham T., Viet, Do Quoc, Huong, DoThi Thu |
| المصدر: | Natural Product Communications ; volume 11, issue 1 ; ISSN 1934-578X 1555-9475 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2016 |
| الوصف: | A variety of new and earlier synthesized lupane, oleanane, ursane and dammarane triterpenoids have been investigated for their inhibitory activity against α-glucosidase. 2,3-Indole-21β-acetyl-20β,28-epoxy-18α,19βH-ursane and 3-oxo-3A-homo-3a-aza-20( S)-hydroxydammar-24(25)-ene were synthesized for the first time. The compounds 3, 4, 8–11 and 14 demonstrated strong in vitro inhibitory activity towards α-glucosidase with IC 50 values of 37.5–115.1 μM. 3-Deoxy-3a-homo-3a-aza-28-cinnamoyloxy-20(29)-lupene, with an IC 50 of 6.67 μM was 60-fold more active than the market drug acarbose. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/1934578x1601100112 |
| DOI: | 10.1177/1934578X1601100112 |
| الاتاحة: | https://doi.org/10.1177/1934578x1601100112 https://journals.sagepub.com/doi/pdf/10.1177/1934578X1601100112 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.645091F5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/1934578x1601100112 |
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