التفاصيل البيبلوغرافية
| العنوان: |
Investigating the Mechanisms and Therapeutic Applications of Chalcones |
| المؤلفون: |
Ahsan Ali Khan, Muhammad Haris, Sobia Haris, Farah Deeba, Mashal Tamsil, Tayaba Basharat, Muhammad Jehangir Khan |
| المصدر: |
Proceedings, Vol 38, Iss 3 (2024) |
| بيانات النشر: |
Shaikh Zayed Medical Complex, Lahore |
| سنة النشر: |
2024 |
| المجموعة: |
Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: |
Chalcones, therapeutic efficacy, mechanisms, analgesic activity, Medicine |
| الوصف: |
Introduction: Chalcones, are a group of organic compounds containing two aromatic rings bridged by a three-carbon -a, ?; unsaturated carbonyl system. This attracted much attention because of their versatility in pharmacological profiles. Aims & Objectives: To investigate the therapeutic efficacy of a particular chalcone derivative, namely (E)-1-(4- bromophenyl)-3-(4-chlorophenyl) prop-2-ene-1-one. Place and Duration of Study: It was conducted in the Pharmacology Laboratory of the Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, and the University of Malakand for about one year. Material & Method: This was a lab-based experimental study. The therapeutic efficacy of a chalcone derivative, (E)-1- (4-bromophenyl)-3-(4-chlorophenyl) prop-2-ene-1-one was assessed through an experiment on pain and inflammation in mice. Claisen-Schmidt condensation reaction and spectroscopic tools were used. Results: Pharmacological data proved a significant decrease in pain and inflammation as compared to Diclofenac Sodium. Reduction of 75.20% in acetic acid-induced writhing as compared to 84.4% with Diclofenac. After 3 hours, there was 67.08% reduction in edema. Conclusion: This study provides evidence that chalcone derivatives in moderation may be effective and safer than present-day drugs that address pain and inflammation. This result may need to be further clinically related to potentially translate them in different patient populations in terms of efficacy and safety. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
http://proceedings-szmc.org.pk/index.php/szmc/article/view/560; https://doaj.org/toc/1815-4905; https://doaj.org/toc/2518-203X; https://doaj.org/article/0a85d08560014c5682e405f884ea21b7 |
| الاتاحة: |
https://doaj.org/article/0a85d08560014c5682e405f884ea21b7 |
| رقم الانضمام: |
edsbas.6426336A |
| قاعدة البيانات: |
BASE |