التفاصيل البيبلوغرافية
| العنوان: |
A Tumor Microenvironment-Triggered and Photothermal-Enhanced Nanocatalysis Multimodal Therapy Platform for Precise Cancer Therapy |
| المؤلفون: |
Ling Qiao (6004562), Yujie Sun (801702), Yaojuan Hu (1910182), Jingjing Fan (302287), Zhongxue Wang (8385969), Ping Wu (46628), Chenxin Cai (1473022) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Pharmacology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, vivo results demonstrate, nir irradiation enhances, exhibits strong absorption, anticancer species generated, target cancer cells, facilitate chemodynamic therapy, inhibit tumor growth, 4 , 2 , precise cancer therapy, efficient cancer therapy, triggered chemical reactions, gt ), respectively, high therapeutic efficiency, 7 , therapeutic efficiency, gas therapy, cancer treatment, cancer cell, tumor microenvironment, high ability, pt therapy |
| الوصف: |
The tumor microenvironment (TME)-triggered therapeutic strategy not only provides effective and economical methods for cancer treatment but also minimizes the side effects on normal tissues. However, anticancer species generated by TME-triggered chemical reactions in situ within cancer cells are insufficient to inhibit tumor growth. This study reports the construction of a TME-triggered and photothermal (PT)-enhanced nanocatalysis platform that is based on cancer cell (MCF-7) membrane-camouflaged hollow porous Cu 7 S 4 nanospheres (HPCu 7 S 4 @MCF-7) for efficient cancer therapy. HPCu 7 S 4 exhibits strong absorption in the near-infrared region with a high PT conversion efficiency (∼30%). After coating with a cell membrane, HPCu 7 S 4 @MCF-7, which possesses a high ability to recognize and target cancer cells, can not only be used as a PT agent for PT therapy (PTT) but can also catalyze the generation of •OH and H 2 S under TME conditions to facilitate chemodynamic therapy (CDT) and gas therapy (GT), respectively. Moreover, NIR irradiation enhances the generation of more •OH and H 2 S to improve the therapeutic efficiency. Both in vitro and in vivo results demonstrate a high therapeutic efficiency of HPCu 7 S 4 @MCF-7-based PTT in combination with TME-triggered and PT-enhanced CDT and GT, which will open a new approach for constructing multimodal therapeutic strategies for potential use in the clinic. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/A_Tumor_Microenvironment-Triggered_and_Photothermal-Enhanced_Nanocatalysis_Multimodal_Therapy_Platform_for_Precise_Cancer_Therapy/17026831 |
| DOI: |
10.1021/acs.chemmater.1c03169.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.chemmater.1c03169.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.64258299 |
| قاعدة البيانات: |
BASE |