Academic Journal
Cortisol-Induced Masculinization: Does Thermal Stress Affect Gonadal Fate in Pejerrey, a Teleost Fish with Temperature-Dependent Sex Determination? Plos One 4(8
| العنوان: | Cortisol-Induced Masculinization: Does Thermal Stress Affect Gonadal Fate in Pejerrey, a Teleost Fish with Temperature-Dependent Sex Determination? Plos One 4(8 |
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| المؤلفون: | Ricardo S. Hattori, Juan I. Fern, Ai Kishii, Hiroyuki Kimura, Tomomi Kinno, Miho Oura, Gustavo M. Somoza, Masashi Yokota, Carlos A. Strüssmann, Seiichi Watanabe |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.iib.unsam.edu.ar/php/papiros/pdf/Hattori2009.pdf. |
| سنة النشر: | 2009 |
| المجموعة: | CiteSeerX |
| الوصف: | Background: Gonadal fate in many reptiles, fish, and amphibians is modulated by the temperature experienced during a critical period early in life (temperature-dependent sex determination; TSD). Several molecular processes involved in TSD have been described but how the animals ‘‘sense’ ’ environmental temperature remains unknown. We examined whether the stress-related hormone cortisol mediates between temperature and sex differentiation of pejerrey, a gonochoristic teleost fish with marked TSD, and the possibility that it involves glucocorticoid receptor- and/or steroid biosynthesis-modulation. Methodology/Principal Findings: Larvae maintained during the period of gonadal sex differentiation at a masculinizing temperature (29uC; 100 % males) consistently had higher cortisol, 11-ketotestoterone (11-KT), and testosterone (T) titres than those at a feminizing temperature (17uC; 100 % females). Cortisol-treated animals had elevated 11-KT and T, and showed a typical molecular signature of masculinization including amh upregulation, cyp19a1a downregulation, and higher incidence of gonadal apoptosis during sex differentiation. Administration of cortisol and a non-metabolizable glucocorticoid receptor (GR) agonist (Dexamethasone) to larvae at a ‘‘sexually neutral’ ’ temperature (24uC) caused significant increases in the proportion of males. Conclusions/Significance: Our results suggest a role of cortisol in the masculinization of pejerrey and provide a possible link |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.580.9380; http://www.iib.unsam.edu.ar/php/papiros/pdf/Hattori2009.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.580.9380 http://www.iib.unsam.edu.ar/php/papiros/pdf/Hattori2009.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.63DCD33E |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |