Academic Journal
Pathogenic mechanisms involving the interplay between adipose tissue and auto-antibodies in rheumatoid arthritis.
| العنوان: | Pathogenic mechanisms involving the interplay between adipose tissue and auto-antibodies in rheumatoid arthritis. |
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| المؤلفون: | Arias-de la Rosa, Iván, Escudero-Contreras, Alejandro, Ruiz-Ponce, Miriam, Cuesta-López, Laura, Román-Rodríguez, Cristóbal, Pérez-Sánchez, Carlos, Ruiz-Limón, Patricia, Ruiz, Rocío Guzman-, Leiva-Cepas, Fernando, Alcaide, Juan, Segui, Pedro, Plasencia, Chamaida, Martinez-Feito, Ana, Font, Pilar, Ábalos, María C, Ortega, Rafaela, Malagón, María M, Tinahones, Francisco J, Collantes-Estévez, Eduardo, López-Pedrera, Chary, Barbarroja, Nuria |
| سنة النشر: | 2022 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Health sciences, Immunology, Rheumatology |
| الوصف: | We aimed to evaluate the association between adipose tissue (AT) dysfunction, autoimmunity, and disease activity in rheumatoid arthritis (RA). A cross-sectional study including 150 RA patients and 50 healthy donors and longitudinal study with 122 RA patients treated with anti-tumor necrosis factor (TNF)-α, anti-interleukin 6 receptor (IL6R) or anti-CD20 therapies for 6 months were carried out. In vitro experiments with human AT and adipocyte and macrophage cell lines were performed. A collagen-induced arthritis mouse model was developed. The insulin resistance and the altered adipocytokine profile were associated with disease activity, the presence of anti-citrullinated proteins anti-bodies (ACPAs), and worse response to therapy in RA. AT in the context of arthritis is characterized by an inflammatory state alongside the infiltration of macrophages and B/plasmatic cells, where ACPAs can have a direct impact, inducing inflammation and insulin resistance in macrophages and promoting a defective adipocyte differentiation, partially restored by biologicals. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2589-0042 |
| Relation: | http://hdl.handle.net/10668/22278; PMC9421387; https://doi.org/10.1016/j.isci.2022.104893; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421387/pdf |
| DOI: | 10.1016/j.isci.2022.104893 |
| الاتاحة: | http://hdl.handle.net/10668/22278 https://doi.org/10.1016/j.isci.2022.104893 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421387/pdf |
| Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; open access |
| رقم الانضمام: | edsbas.63D8A6F2 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 25890042 |
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| DOI: | 10.1016/j.isci.2022.104893 |