التفاصيل البيبلوغرافية
| العنوان: |
Male infertility in Sertoli cell-only syndrome: An investigation of autosomal gene defects |
| المؤلفون: |
Koc, G., Ozdemir, A.A., Girgin, G., Akbal, C., Kirac, D., Avcilar, T., Guney, A.I. |
| المساهمون: |
Koc, G., Ozdemir, A.A., Girgin, G., Akbal, C., Kirac, D., Avcilar, T., Guney, A.I., Yeditepe Üniversitesi |
| بيانات النشر: |
Blackwell Publishing |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
array comparative genomic hybridization, infertility, Sertoli cell-only syndrome |
| الوصف: |
Objectives: To detect autosomal genetic defects and to determine candidate genes in Sertoli cell-only syndrome infertile men. Methods: Single-nucleotide polymorphism + comparative genomic hybridization microarray technology was carried out on 39 Sertoli cell-only syndrome infertile patients in the present study. Array comparative genomic hybridization compares the patient's genome against a reference genome, and identifies uncover deletions, amplifications and loss of heterozygosity. Results: A link between defective spermatogenesis genes and infertility was examined, and amplifications and deletions in several genes were detected, including homeobox gene; synaptonemal complex element protein 1; collagen, type I, alpha 1; imprinted maternally expressed transcript; and potassium voltage-gated channel subfamily Q member 1. Conclusions: The present data suggest that several genes can play an important role in spermatogenesis and progression of Sertoli cell-only syndrome. © 2018 The Japanese Urological Association ; BSAGC-YLP-040112-0002 ; This study was supported by a grant from the Research Foundation of Marmara University, Turkey (Project No: BSAGC-YLP-040112-0002). |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
09198172 |
| Relation: |
International Journal of Urology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; PubMed ID: 30478911; 292; 298; 26; https://hdl.handle.net/20.500.11831/361 |
| الاتاحة: |
https://hdl.handle.net/20.500.11831/361 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.63C88CEF |
| قاعدة البيانات: |
BASE |