Academic Journal
Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation?
| العنوان: | Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation? |
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| المؤلفون: | Guinde, Julien, Frankel, Diane, Perrin, Sophie, Delecourt, Valerie, Levy, Nicolas, Barlesi, Fabrice, Astoul, Philippe, Roll, Patrice, Kaspi, Elise |
| المساهمون: | Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Nord CHU - APHM, Laboratoire de Biologie Cellulaire Hôpital de la Timone - APHM, Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Timone CHU - APHM (TIMONE), Aix Marseille Université (AMU), ProGeLife Marseille, Département de génétique médicale Hôpital de la Timone - APHM, Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Timone CHU - APHM (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance Publique - Hôpitaux de Marseille (APHM), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes (IPC), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 2073-4409 ; Cells ; https://amu.hal.science/hal-01991352 ; Cells, 2018, 7 (7), ⟨10.3390/cells7070078⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2018 |
| المجموعة: | Aix-Marseille Université: HAL |
| مصطلحات موضوعية: | lung cancer, lamins, microRNAs, lung adenocarcinoma, miR-9, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics |
| الوصف: | International audience ; Lung cancer represents the primary cause of cancer death in the world. Malignant cells identification and characterization are crucial for the diagnosis and management of patients with primary or metastatic cancers. In this context, the identification of new biomarkers is essential to improve the differential diagnosis between cancer subtypes, to select the most appropriate therapy, and to establish prognostic correlations. Nuclear abnormalities are hallmarks of carcinoma cells and are used as cytological diagnostic criteria of malignancy. Lamins (divided into A- and B-types) are localized in the nuclear matrix comprising nuclear lamina, where they act as scaffolding protein, involved in many nuclear functions, with regulatory effects on the cell cycle and differentiation, senescence and apoptosis. Previous studies have suggested that lamins are involved in tumor development and progression with opposite results concerning their prognostic role. This review provides an overview of lamins expression in lung cancer and the relevance of these findings for disease diagnosis and prognosis. Furthermore, we discuss the link between A-type lamins expression in lung carcinoma cells and nuclear deformability, epithelial to mesenchymal transition, and metastatic potential, and which mechanisms could regulate A-type lamins expression in lung cancer, such as the microRNA miR-9. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/30012957; hal-01991352; https://amu.hal.science/hal-01991352; https://amu.hal.science/hal-01991352/document; https://amu.hal.science/hal-01991352/file/cells-de%CC%81potHAL.pdf; PUBMED: 30012957; PUBMEDCENTRAL: PMC6071028 |
| DOI: | 10.3390/cells7070078 |
| الاتاحة: | https://amu.hal.science/hal-01991352 https://amu.hal.science/hal-01991352/document https://amu.hal.science/hal-01991352/file/cells-de%CC%81potHAL.pdf https://doi.org/10.3390/cells7070078 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.63A4BAAF |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cells7070078 |
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