التفاصيل البيبلوغرافية
| العنوان: |
Integrative epigenomics in Sjögren's syndrome reveals novel pathways and a strong interaction between the HLA, autoantibodies and the interferon signature |
| المؤلفون: |
Teruel, MarÃa, Barturen, Guillermo, MartÃnez-Bueno, Manuel, Castellini-Pérez, Olivia, Barroso-Gil, Miguel, Povedano, Elena, Kerick, Martin, Català -Moll, Francesc, Makowska, Zuzanna, Buttgereit, Anne, Beretta, Lorenzo, Vigone, Barbara, Pers, Jacques Olivier, Saraux, Alain, Devauchelle-Pensec, Valérie, Cornec, Divi, Jousse-Joulin, Sandrine, Lauwerys, Bernard, Ducreux, Julie, Maudoux, Anne-Lise, Vasconcelos, Carlos, Tavares, Ana, Neves, Esmeralda, Faria, Raquel, Brandão, Mariana, Campar, Ana, Marinho, António, Farinha, Fátima, Almeida, Isabel, Gozalez-Gay Mantecón, Miguel Angel, Blanco, Ricardo, Corrales MartÃnez, Alfonso, Cervera, Ricard, RodrÃguez-Pintó, Ignasi, Espinosa, Gerard, Lories, Rik, De Langhe, Ellen, Hunzelmann, Nicolas, Belz, Doreen, Witte, Torsten, Baerlecken, Niklas, Stummvoll, Georg, Zauner, Michael, Lehner, Michaela, Collantes Estevéz, Eduardo, Ortega-Castro, Rafaela, Aguirre, Mª Angeles, Escudero-Contreras, Alejandro, Castro-Villegas, Ma Carmen, Ortego-Centeno, Norberto, Fernández Roldán, MarÃa Concepción, Raya, Enrique, Jiménez Moleón, Inmaculada, de Ramon, Enrique, DÃaz Quintero, Isabel, Meroni, Pier Luigi, Gerosa, Maria, Schioppo, Tommaso, Artusi, Carolina, Chizzolini, Carlo, Zuber, Aleksandra, Wynar, Donatienne, Kovács, Laszló, Balog, Attila, Deák, Magdolna, Bocskai, Márta, Dulic, Sonja, Kádár, Gabriella, Hiepe, Falk, Gerl, Velia, Thiel, Silvia, Rodriguez Maresca, Manuel, López-Berrio, Antonio, Aguilar-Quesada, RocÃo, Navarro-Linares, Héctor, Ãlvarez, Montserrat, Alvarez‑Errico, Damiana, Azevedo, Nancy, Barbarroja, Nuria, Cheng, Qingyu, Cremer, Jonathan, De Groof, Aurélie, Dufour, Aleksandra, Hernandez‑Fuentes, Maria, Khodadadi, Laleh, Kniesch, Katja, Li, Tianlu, Lopez‑Pedrera, Chary, Marañón, Concepción, Muchmore, Brian, Rouvière, Bénédicte, Simon, Quentin, Trombetta, Elena, Varela, Nieves, Ballestar, Esteban, Martin, Javier, Carnero-Montoro, Elena, Alarcón-Riquelme, Marta E, Universitat Autònoma de Barcelona |
| سنة النشر: |
2021 |
| المجموعة: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| مصطلحات موضوعية: |
Autoantibodies, DNA Methylation, Epigenomics, Female, Gene Expression, Gene Expression Regulation, Genetic Variation, HLA Antigens, Humans, Interferons, Male, Sjogren's Syndrome |
| الوصف: |
Primary Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration and damage of exocrine salivary and lacrimal glands. The etiology of SS is complex with environmental triggers and genetic factors involved. By conducting an integrated multi-omics study, we confirmed a vast coordinated hypomethylation and overexpression effects in IFN-related genes, what is known as the IFN signature. Stratified and conditional analyses suggest a strong interaction between SS-associated HLA genetic variation and the presence of Anti-Ro/SSA autoantibodies in driving the IFN epigenetic signature and determining SS. We report a novel epigenetic signature characterized by increased DNA methylation levels in a large number of genes enriched in pathways such as collagen metabolism and extracellular matrix organization. We identified potential new genetic variants associated with SS that might mediate their risk by altering DNA methylation or gene expression patterns, as well as disease-interacting genetic variants that exhibit regulatory function only in the SS population. Our study sheds new light on the interaction between genetics, autoantibody profiles, DNA methylation and gene expression in SS, and contributes to elucidate the genetic architecture of gene regulation in an autoimmune populatio |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
20452322 |
| Relation: |
Ministerio de EconomÃa y Competitividad FJCI_2014_20652; European Commission. Horizon 2020 806975; Scientific reports; Vol. 11 Núm. 1 (december 2021), p. 23292; https://ddd.uab.cat/record/270518; urn:oai:ddd.uab.cat:270518; urn:scopus_id:85120859047; urn:articleid:20452322v11n1p23292; urn:pmid:34857786; urn:pmcid:PMC8640069; urn:oai:pubmedcentral.nih.gov:8640069 |
| الاتاحة: |
https://ddd.uab.cat/record/270518 |
| Rights: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.639F7E71 |
| قاعدة البيانات: |
BASE |
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