Academic Journal
Outcomes of on-label reduced-dose edoxaban in octogenarian patients with atrial fibrillation
| العنوان: | Outcomes of on-label reduced-dose edoxaban in octogenarian patients with atrial fibrillation |
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| المؤلفون: | Lee, H J, Lee, S H, Kim, J W, Kim, J Y, Park, S J, Park, K M, On, Y K |
| المصدر: | Europace ; volume 26, issue Supplement_1 ; ISSN 1099-5129 1532-2092 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2024 |
| الوصف: | Background Non-vitamin K antagonist oral anticoagulants (NOACs) are effective in preventing thromboembolisms and reduce the risk of bleeding compared with warfarin. There are few reports on the outcomes of on-label reduced-dose NOACs. Purpose The aim of this study was to assess the safety and efficacy of on-label reduced-dose edoxaban in octogenarian patients with atrial fibrillation (AF). Methods This study is a multi-center, prospective, non-interventional study to evaluate the safety and efficacy of on-label reduced-dose edoxaban in patients with AF. We evaluated outcomes of major bleeding, stroke or systemic embolism, all-cause death, and composite clinical outcomes. Results A total of 2448 patients (mean age 75.0±8.3 years, 801 [32.7%] males) was included in the present study. 932 patients (38.1%) were octogenarians. Major bleeding events occurred at a rate of 1.69%/yr in octogenarian patients and 0.9%/yr in non-octogenarian patients. The event rate of strokes and systemic embolisms was 1.93%/yr in octogenarian patients and 0.66%/yr in non-octogenarian patients The overall net clinical outcomes occurred at a rate of 5.45%/yr in octogenarian patients and 2.24%/yr in non-octogenarian patients. Conclusions Reduced-dose edoxaban can be used safely in Asian patients with very elderly patients. Older age was associated with a higher risk of ischemic stroke and composite adverse events. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/europace/euae102.240 |
| الاتاحة: | http://dx.doi.org/10.1093/europace/euae102.240 https://academic.oup.com/europace/article-pdf/26/Supplement_1/euae102.240/57871931/euae102.240.pdf |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.638CA0F8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/europace/euae102.240 |
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