التفاصيل البيبلوغرافية
| العنوان: |
Broad Adaptability of Coronavirus Adhesion Revealed from the Complementary Surface Affinity of Membrane and Spikes |
| المؤلفون: |
García-Arribas, Aritz B., Ibáñez-Freire, Pablo, Carlero, Diego, Palacios-Alonso, Pablo, Cantero-Reviejo, Miguel, Ares, Pablo, López-Polín, Guillermo, Yan, Han, Wang, Yan, Sarkar, Soumya, Chhowalla, Manish, Oksanen, Hanna M., Martín-Benito, Jaime, de Pablo, Pedro J., Delgado-Buscalioni, Rafael |
| المساهمون: |
Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences Research Programme, Faculty Common Matters (Faculty of Biology and Environmental Sciences), Molecular Principles of Viruses |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2024 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
atomic-force-microscopy, coarse-graining models, coronavirus, elastic theory, surface-affinity, Biochemistry, cell and molecular biology, 11832 Microbiology and virology |
| الوصف: |
Coronavirus stands for a large family of viruses characterized by protruding spikes surrounding a lipidic membrane adorned with proteins. The present study explores the adhesion of transmissible gastroenteritis coronavirus (TGEV) particles on a variety of reference solid surfaces that emulate typical virus-surface interactions. Atomic force microscopy informs about trapping effectivity and the shape of the virus envelope on each surface, revealing that the deformation of TGEV particles spans from 20% to 50% in diameter. Given this large deformation range, experimental Langmuir isotherms convey an unexpectedly moderate variation in the adsorption-free energy, indicating a viral adhesion adaptability which goes beyond the membrane. The combination of an extended Helfrich theory and coarse-grained simulations reveals that, in fact, the envelope and the spikes present complementary adsorption affinities. While strong membrane-surface interaction lead to highly deformed TGEV particles, surfaces with strong spike attraction yield smaller deformations with similar or even larger adsorption-free energies. ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
A.G.\u2010A., R. D.\u2010B. and P. J. d. P. acknowledge support by grant from the Madrid Community Government and the REACT\u2010EU program (VIRMAT project). P. J. d. P. acknowledges support by grants from the Spanish Ministry of Economy, Industry and Competitiveness projects (FIS2017\u2010 89549\u2010R and FIS2017\u201090701\u2010 REDT), the Human Frontiers Science Program (HFSPO RGP0012/2018) and Fondo SUPERA COVID19 Santander CRUE project TEXGRAF. J. M.\u2010B. acknowledges support by grants from the Spanish Ministry of Science and Innovation projects (PID2020\u2010117752RB\u2010I00 and BFU2017\u201090018\u2010R), CSIC project (PIE202020E079\u20106) and Fondo SUPERA COVID19 Santander CRUE project TEXGRAF. The authors acknowledge access to the cryoEM CNB\u2010CSIC facility in the context of the CRIOMECORR project (ESFRI\u20102019\u201001\u2010CSIC\u201016). R. D.\u2010B. acknowledges support from the Spanish Ministry of Economy, Industry and Competitiveness under projects FIS2020\u2010 117080RB\u2010C51 and Prueba de Concepto PDC2021\u2010121441\u2010C21.; García-Arribas , A B , Ibáñez-Freire , P , Carlero , D , Palacios-Alonso , P , Cantero-Reviejo , M , Ares , P , López-Polín , G , Yan , H , Wang , Y , Sarkar , S , Chhowalla , M , Oksanen , H M , Martín-Benito , J , de Pablo , P J & Delgado-Buscalioni , R 2024 , ' Broad Adaptability of Coronavirus Adhesion Revealed from the Complementary Surface Affinity of Membrane and Spikes ' , Advanced Science . https://doi.org/10.1002/advs.202404186; ORCID: /0000-0003-3047-8294/work/167512637; http://hdl.handle.net/10138/585735; 6af9f0bd-b989-47a7-8ec3-4c9ba83bb085; 85203016543 |
| الاتاحة: |
http://hdl.handle.net/10138/585735 |
| Rights: |
cc_by ; info:eu-repo/semantics/openAccess ; openAccess |
| رقم الانضمام: |
edsbas.63833624 |
| قاعدة البيانات: |
BASE |