Academic Journal
Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women.
| العنوان: | Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women. |
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| المؤلفون: | Lum, Fok-Moon, Narang, Vipin, Hue, Susan, Chen, Jie, McGovern, Naomi, Rajarethinam, Ravisankar, Tan, Jeslin Jl, Amrun, Siti Naqiah, Chan, Yi-Hao, Lee, Cheryl Yp, Chua, Tze-Kwang, Yee, Wearn-Xin, Yeo, Nicholas Kw, Tan, Thiam-Chye, Liu, Xuan, Haldenby, Sam, Leo, Yee-Sin, Ginhoux, Florent, Chan, Jerry Ky, Hiscox, Julian, Chong, Chia-Yin, Ng, Lisa Fp |
| المصدر: | nlmid: 101638268 ; essn: 2050-0068 |
| بيانات النشر: | Wiley //dx.doi.org/10.1002/cti2.1082 Clin Transl Immunology |
| سنة النشر: | 2019 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | RNA‐seq, Zika virus, histology, infection, placenta, transcriptomics |
| الوصف: | OBJECTIVES: Effects of Zika virus (ZIKV) infection on placental development during pregnancy are unclear. METHODS: Full-term placentas from three women, each infected with ZIKV during specific pregnancy trimesters, were harvested for anatomic, immunologic and transcriptomic analysis. RESULTS: In this study, each woman exhibited a unique immune response with raised IL-1RA, IP-10, EGF and RANTES expression and neutrophil numbers during the acute infection phase. Although ZIKV NS3 antigens co-localised to placental Hofbauer cells, the placentas showed no anatomic defects. Transcriptomic analysis of samples from the placentas revealed that infection during trimester 1 caused a disparate cellular response centred on differential eIF2 signalling, mitochondrial dysfunction and oxidative phosphorylation. Despite these, the babies were delivered without any congenital anomalies. CONCLUSION: These findings should translate to improve clinical prenatal screening procedures for virus-infected pregnant patients. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://www.repository.cam.ac.uk/handle/1810/299855 |
| DOI: | 10.17863/CAM.46928 |
| الاتاحة: | https://doi.org/10.17863/CAM.46928 https://www.repository.cam.ac.uk/handle/1810/299855 |
| Rights: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.63731645 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.46928 |
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