Academic Journal
Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes
| العنوان: | Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes |
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| المؤلفون: | Sun, Jingru, Singh, Varsha, Kajino-Sakamoto, Rie, Aballay, Alejandro |
| بيانات النشر: | United States |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Pseudomonas aeruginosa - immunology, Caenorhabditis elegans - microbiology, Up-Regulation, Genes, Helminth, Stress, Physiological, Caenorhabditis elegans Proteins - metabolism, Endoplasmic Reticulum - metabolism, Intestines - metabolism, Pseudomonas aeruginosa - pathogenicity, Sensory Receptor Cells - physiology, Transcription, Genetic, Membrane Proteins - metabolism, Receptors, G-Protein-Coupled - physiology, Signal Transduction, Unfolded Protein Response - genetics, Caenorhabditis elegans - genetics, Membrane Proteins - genetics, Down-Regulation, Pharynx - metabolism, Bacterial Load, Immunity, Innate, Caenorhabditis elegans - immunology, Animals, Mitogen-Activated Protein Kinases - genetics, Caenorhabditis elegans Proteins - physiology |
| الوصف: | The unfolded protein response (UPR), which is activated when unfolded or misfolded proteins accumulate in the endoplasmic reticulum, has been implicated in the normal physiology of immune defense and in several human diseases, including diabetes, cancer, neurodegenerative disease, and inflammatory disease. In this study, we found that the nervous system controlled the activity of a noncanonical UPR pathway required for innate immunity in Caenorhabditis elegans. OCTR-1, a putative octopamine G protein-coupled catecholamine receptor (GPCR, G protein-coupled receptor), functioned in sensory neurons designated ASH and ASI to actively suppress innate immune responses by down-regulating the expression of noncanonical UPR genes pqn/abu in nonneuronal tissues. Our findings suggest a molecular mechanism by which the nervous system may sense inflammatory responses and respond by controlling stress-response pathways at the organismal level. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | ispartof: Science (American Association for the Advancement of Science) spage 729 epage 732 issue 6030 vol 332; WOS:000290265800046; 2376/108933; https://doi.org/10.1126/science.1203411; 99900547386601842; alma:01ALLIANCE_WSU/bibs/99900547386601842 |
| DOI: | 10.1126/science.1203411 |
| الاتاحة: | https://doi.org/10.1126/science.1203411 https://rex.libraries.wsu.edu/esploro/outputs/journalArticle/Neuronal-GPCR-controls-innate-immunity-by/99900547386601842 |
| رقم الانضمام: | edsbas.6326D1CB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1126/science.1203411 |
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