Academic Journal
Proinflammatory pattern in the lower airways of non-asthmatic obese adolescents.
| العنوان: | Proinflammatory pattern in the lower airways of non-asthmatic obese adolescents. |
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| المؤلفون: | Gutmann, Desiree, Dressler, Melanie, Eickmeier, Olaf, Herrmann, Eva, Kirwil, Marta, Schubert, Ralf, Zielen, Stefan, Zissler, Ulrich M |
| المساهمون: | Lehrstuhl für Molekulare Allergologie und Umweltforschung (Prof. Schmidt-Weber) |
| سنة النشر: | 2024 |
| المجموعة: | Munich University of Technology (TUM): mediaTUM |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc |
| الوصف: | BACKGROUND: Obesity is known to be a pro-inflammatory condition affecting multiple organs. Obesity as a systemic pro-inflammatory state, might be associated with bronchial inflammation in non-smoking adolescents with a BMI ≥ 30 kg/m2 without evidence of concomitant chronic diseases. MATERIALS AND METHODS: We studied non-asthmatic obese patients (n = 20; median age 15.8 years; BMI 35.0 kg/m2) compared to age matched healthy control subjects (n = 20; median age 17.5 years; BMI 21.5 kg/m2). Induced sputum differential cell counts and sputum mRNA levels were assessed for all study subjects. Serum levels of CRP, IL-6, and IL-8 were measured. Further, IL-5, IL-6, IL-8, IL-13, IL-17, TNF-α, IFN-γ, and IP-10 protein levels were analyzed in induced sputum was. RESULTS: Serum CRP levels, sputum inflammatory cell load and sputum eosinophils differed significantly between obese and non-obese subjects, for sputum neutrophils, a correlation was shown with BMI ≥ 30 kg/m2. Differences were also observed for sputum mRNA expression of IL6, IL8, IL13, IL17, IL23, and IFN-γ, as well as the transcription factors T-bet, GATA3, and FoxP3. CONCLUSIONS: Increased bronchial inflammation, triggered by systemic or local inflammatory effects of obesity itself, may account for the higher rates of airway disease in obese adolescents. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://mediatum.ub.tum.de/1741391 |
| DOI: | 10.1016/j.cyto.2023.156452 |
| الاتاحة: | https://mediatum.ub.tum.de/1741391 https://doi.org/10.1016/j.cyto.2023.156452 |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.62E73C27 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cyto.2023.156452 |
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