Academic Journal
No apparent effect of naproxen on CSFmarkers of innate immune activation
| العنوان: | No apparent effect of naproxen on CSFmarkers of innate immune activation |
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| المؤلفون: | Meyer, Pierre‐François, Labonté, Anne, Rosa‐Neto, Pedro, Poirier, Judes, Breitner, John C. S. |
| المساهمون: | McGill University, Government of Canada, Fonds de Recherche du Québec - Santé, Fondation Jean-Louis Lévesque |
| المصدر: | Annals of Clinical and Translational Neurology ; volume 6, issue 6, page 1127-1133 ; ISSN 2328-9503 2328-9503 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2019 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | We studied 78 participants having a parental or multiple‐sibling history of Alzheimer’s disease (AD) in a two‐year randomized placebo‐controlled trial of naproxen 220 mg b.i.d. for mitigation of early AD pathogenesis. Naproxen was detected in cerebrospinal fluid at concentrations ~100 times lower than in plasma, but produced negligible change in immune markers. The repeated lack of benefit in AD prevention trials using naproxen and related drugs may reflect limited CNS permeability, lack of expected drug effects, or both. These findings suggest reconsideration of implications from results of AD prevention trials using anti‐inflammatory drugs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/acn3.788 |
| الاتاحة: | http://dx.doi.org/10.1002/acn3.788 https://onlinelibrary.wiley.com/doi/pdf/10.1002/acn3.788 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/acn3.788 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.629F5967 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/acn3.788 |
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