التفاصيل البيبلوغرافية
| العنوان: |
Tubuloglomerular feedback control of glomerular filtration rate is preserved in connexin 40‐deficient mice |
| المؤلفون: |
Oppermann, Mona, Castrop, Hayo, Eisner, Christoph, Schnermann, Jurgen |
| المصدر: |
The FASEB Journal ; volume 25, issue S1 ; ISSN 0892-6638 1530-6860 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2011 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
The gap junctional protein connexin 40 (Cx40) is highly expressed in the extraglomerular mesangium connecting the tubular epithelium at the macula densa and the afferent arteriole. Participation of Cx40 in juxtaglomerular communication is suggested by the finding that the expression of renin and the localization of renin‐expressing cells are greatly abnormal in Cx40‐deficient mice. In the present experiments we have therefore used wild type and Cx40−/− mice to determine the role of connexin 40 in tubuloglomerular feedback (TGF). Stop flow pressure (Psf) assessed by micropuncture fell from 40.0±1.7 to 34.5±1.7 mmHg in C57Bl/6 wild type mice, and from 31.3±1.0 to 26.9±0.9 mmHg in Cx40−/− mice. Psf changes of 5.5±0.5 mmHg in wild type and of 4.4±0.5 in Cx40−/− mice were not significantly different (p=0.125). Psf values were significantly lower in Cx40−/− than wild type mice at all flow rates. Arterial blood pressure was not different between wild type and Cx40−/− mice. Glomerular filtration rate (GFR) of conscious mice was lower in Cx40−/− than wild types and this difference increased with aging. We conclude that TGF responsiveness is well maintained in the absence of connexin 40 suggesting that coupling through this dominant mesangial protein is not required for tubulo‐vascular communication. Renal vascular resistance appears to be elevated in Cx40−/− mice, perhaps a consequence of the elevated plasma renin levels. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1096/fasebj.25.1_supplement.lb630 |
| الاتاحة: |
http://dx.doi.org/10.1096/fasebj.25.1_supplement.lb630 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: |
edsbas.6288992D |
| قاعدة البيانات: |
BASE |