التفاصيل البيبلوغرافية
| العنوان: |
Click-to-Chelate: Development of Technetium and Rhenium-Tricarbonyl Labeled Radiopharmaceuticals |
| المؤلفون: |
Christiane Kluba, Thomas Mindt |
| المصدر: |
Molecules; Volume 18; Issue 3; Pages: 3206-3226 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2013 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
CuAAC, Click-to-Chelate, radiolabeling, radiopharmaceuticals, 99m Tc-tricarbonyl, 186/188 Re-tricarbonyl |
| جغرافية الموضوع: |
agris |
| الوصف: |
The Click-to-Chelate approach is a highly efficient strategy for the radiolabeling of molecules of medicinal interest with technetium and rhenium-tricarbonyl cores. Reaction of azide-functionalized molecules with alkyne prochelators by the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC; click reaction) enables the simultaneous synthesis and conjugation of tridentate chelating systems for the stable complexation of the radiometals. In many cases, the functionalization of (bio)molecules with the ligand system and radiolabeling can be achieved by convenient one-pot procedures. Since its first report in 2006, Click-to-Chelate has been applied to the development of numerous novel radiotracers with promising potential for translation into the clinic. This review summarizes the use of the Click-to-Chelate approach in radiopharmaceutical sciences and provides a perspective for future applications. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://dx.doi.org/10.3390/molecules18033206 |
| DOI: |
10.3390/molecules18033206 |
| الاتاحة: |
https://doi.org/10.3390/molecules18033206 |
| Rights: |
https://creativecommons.org/licenses/by/3.0/ |
| رقم الانضمام: |
edsbas.627E958A |
| قاعدة البيانات: |
BASE |