Academic Journal
Comparison of the immunological and virological responses to cART between HIV-1/O and HIV-1/M patients followed up in France
| العنوان: | Comparison of the immunological and virological responses to cART between HIV-1/O and HIV-1/M patients followed up in France |
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| المؤلفون: | Unal, Guillemette, Seng, Rémonie, Alessandri-Gradt, Elodie, Plessis, Lorraine, Ghislain, Mathilde, Goujard, Cécile, Leoz, Marie, Plantier, Jean-Christophe, Meyer, Laurence, Duvivier, Claudine, Touam, Fatima, Pialoux, Gilles, Le Nagat, Sophie, Slama, Laurence, Chas, Julie, L’Yavanc, Thomas, Capeau, Jacqueline, Vigouroux, Corinne, Fellahi, Soraya, Bastard, Jean-Philippe, Viard, Jean-Paul, Maignan, Aline, Cros, Agnès, Sobel, Alain, Gérard, Laurence, Séréni, Daniel, Van Dien, Le, Molina, Jean-Michel, Lascoux-Combe, Caroline, Aslan, Alexandre, Balkan, Suna, de Verdière, Nathalie Colin, De Castro, Nathalie, Delgado, Jeanine, Parlier, Sylvie, Pintado, Claire, Ponscarme, Diane, Rozenbaum, Willy, Taulera, Olivier, Gallien, Sébastien, Garrait, Valérie, Gatey, Caroline, Gazaignes, Sandrine, Goguel, Jérôme, Lafaurie, Matthieu, Munier, Anne-Lise, Bergmann, Jean-François, Rami, Agathe, Parrinello, Maguy, Girard, Pierre-Marie |
| المساهمون: | Agence Nationale de Recherches sur le Sida et les hépatites virales, Sidaction, Rouen University Hospital |
| المصدر: | Journal of Antimicrobial Chemotherapy ; ISSN 0305-7453 1460-2091 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2025 |
| الوصف: | Background Therapeutic outcomes for patients infected by genetically divergent HIV-1/O are not well-known due to scarce data and the lack of an appropriate comparison with patients infected by pandemic HIV-1/M. We aimed to compare the immunological and virological response to cART between HIV-1/O and HIV-1/M patients followed in France. Methods All naïve HIV-1/O subjects initiating cART in France in ANRS-ORIVAO study were compared to naïve HIV-1/M subjects initiating cART in ANRS-COPANA cohort. Piecewise linear mixed-effect models and Kaplan–Meier survival curves were used to analyse immunological and virological response to cART overall (65 HIV-1/O versus 279 HIV-1/M), then only in patients initiating 2INTI + 1PI/r. Results Plasma viral load (pVL) at treatment initiation was 0.6 log10 copies/mL lower in HIV-1/O than in HIV-1/M patients (P = 0.004) in the overall population, but there was no difference in the time to pVL < 200 cp/mL after cART initiation (log rank test, P = 0.57). Meanwhile, baseline CD4 counts were lower in HIV-1/O (median 180/mm3) than HIV-1/M (248/mm3) patients (P = 0.001). At 4 months, the increase in CD4 counts did not differ (P = 0.96) between groups but remained lower in HIV-1/O patients beyond 4 months of treatment (P = 0.04). In PI/r population, baseline pVL was 1 log10 copies/mL lower for HIV-1/O than HIV-1/M patients, leading to significantly faster attainment of pVL < 200 cp/mL (log rank test: P < 0.001); immunological response to cART was similar. Conclusions HIV-1/O and HIV-1/M immunological and virological responses to cART did not differ when epidemiological characteristics of the patients were taken into account. In France, treating HIV-1/O following HIV-1/M guidelines leads to similar therapeutic outcomes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/jac/dkae475 |
| DOI: | 10.1093/jac/dkae475/61428622/dkae475.pdf |
| الاتاحة: | https://doi.org/10.1093/jac/dkae475 https://academic.oup.com/jac/advance-article-pdf/doi/10.1093/jac/dkae475/61428622/dkae475.pdf |
| Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
| رقم الانضمام: | edsbas.626DA51D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/jac/dkae475 |
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