Academic Journal
Mesoscopic Rigid Body Modelling of the Extracellular Matrix Self-Assembly
| العنوان: | Mesoscopic Rigid Body Modelling of the Extracellular Matrix Self-Assembly |
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| المؤلفون: | Wong Hua, Prévoteau-Jonquet Jessica, Baud Stéphanie, Dauchez Manuel, Belloy Nicolas |
| المصدر: | Journal of Integrative Bioinformatics, Vol 15, Iss 2, Pp 690-1 (2018) |
| بيانات النشر: | De Gruyter |
| سنة النشر: | 2018 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | interactive simulation, rigid bodies, virtual reality, Biotechnology, TP248.13-248.65 |
| الوصف: | The extracellular matrix (ECM) plays an important role in supporting tissues and organs. It even has a functional role in morphogenesis and differentiation by acting as a source of active molecules (matrikines). Many diseases are linked to dysfunction of ECM components and fragments or changes in their structures. As such it is a prime target for drugs. Because of technological limitations for observations at mesoscopic scales, the precise structural organisation of the ECM is not well-known, with sparse or fuzzy experimental observables. Based on the Unity3D game and physics engines, along with rigid body dynamics, we propose a virtual sandbox to model large biological molecules as dynamic chains of rigid bodies interacting together to gain insight into ECM components behaviour in the mesoscopic range. We have preliminary results showing how parameters such as fibre flexibility or the nature and number of interactions between molecules can induce different structures in the basement membrane. Using the Unity3D game engine and virtual reality headset coupled with haptic controllers, we immerse the user inside the corresponding simulation. Untrained users are able to navigate a complex virtual sandbox crowded with large biomolecules models in a matter of seconds. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1613-4516 |
| Relation: | https://doi.org/10.1515/jib-2018-0009; https://doaj.org/toc/1613-4516; https://doaj.org/article/a118cf72595a497189e07595a061c844 |
| DOI: | 10.1515/jib-2018-0009 |
| الاتاحة: | https://doi.org/10.1515/jib-2018-0009 https://doaj.org/article/a118cf72595a497189e07595a061c844 |
| رقم الانضمام: | edsbas.625B3C47 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16134516 |
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| DOI: | 10.1515/jib-2018-0009 |