Academic Journal
Primary Thrombophilia XVI: A Look at the Genotype of the Sticky Platelet Syndrome Phenotype
| العنوان: | Primary Thrombophilia XVI: A Look at the Genotype of the Sticky Platelet Syndrome Phenotype |
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| المؤلفون: | Elizabeth García-Villaseñor MD, Lorena Bojalil-Álvarez MD, Iván Murrieta-Álvarez MD, Yahveth Cantero-Fortiz MD, Guillermo J. Ruiz-Delgado MD, FACP, Guillermo J. Ruiz-Argüelles MD, FRCP, MACP, DSc (hc) |
| المصدر: | Clinical and Applied Thrombosis/Hemostasis, Vol 27 (2021) |
| بيانات النشر: | SAGE Publishing |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | The sticky platelet syndrome (SPS) was described by Mammen in 1983. Since then, scientists in several countries have identified the condition and published cases or series of patients, thus enabling the description of the prevalence of the inherited condition, its salient clinical features, and the treatment of the disease. The diagnosis of the SPS phenotype requires fresh blood samples and special equipment which is not available in all coagulation laboratories. In the era of molecular biology, up to now it has not been possible to define a clear association of the SPS phenotype with a specific molecular marker. Some molecular changes which have been described in platelet proteins in some persons with the phenotype of the SPS are here discussed. Nowadays, the SPS phenotype may be considered as a risk factor for thrombosis and most cases of the SPS developing vaso-occlussive episodes are the result of its coexistence with other thrombosis-prone conditions, some of the inherited and some of them acquired, thus leading to the concept of multifactorial thrombophilia. Ignoring all these evidence-based concepts is inappropriate, same as stating that the SPS is a nonentity simply because not all laboratories are endowed with adequate equipment to support the diagnosis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1938-2723 |
| Relation: | https://doi.org/10.1177/10760296211044212; https://doaj.org/toc/1938-2723; https://doaj.org/article/247e8446ca8d4821b06c4224c06bd735 |
| DOI: | 10.1177/10760296211044212 |
| الاتاحة: | https://doi.org/10.1177/10760296211044212 https://doaj.org/article/247e8446ca8d4821b06c4224c06bd735 |
| رقم الانضمام: | edsbas.6257EA79 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19382723 |
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| DOI: | 10.1177/10760296211044212 |