Academic Journal
EFFECT OF ANTICOAGULANT TREATMENT OF DABIGATRAN AND WARFARIN ON HEMOSTASIS IN PATIENTS WITH LIVER CIRRHOSIS AND ATRIAL FIBRILATION. ; ЕФЕКТ ВПЛИВУ АНТИКОАГУЛЯНТНИХ ПРЕПАРАТІВ ДАБІГАТРАНУ ТА ВАРФАРИНУ НА ПОКАЗНИКИ СТАНУ ГЕМОСТАЗУ У ПАЦІЄНТІВ З ЦИРОЗОМ ПЕЧІНКИ ТА ФІБРИЛЯЦІЄЮ ПЕРЕДСЕРДЬ
| العنوان: | EFFECT OF ANTICOAGULANT TREATMENT OF DABIGATRAN AND WARFARIN ON HEMOSTASIS IN PATIENTS WITH LIVER CIRRHOSIS AND ATRIAL FIBRILATION. ; ЕФЕКТ ВПЛИВУ АНТИКОАГУЛЯНТНИХ ПРЕПАРАТІВ ДАБІГАТРАНУ ТА ВАРФАРИНУ НА ПОКАЗНИКИ СТАНУ ГЕМОСТАЗУ У ПАЦІЄНТІВ З ЦИРОЗОМ ПЕЧІНКИ ТА ФІБРИЛЯЦІЄЮ ПЕРЕДСЕРДЬ |
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| المؤلفون: | Baylo, A.E., Maksymets, T.O., Shypulіn, V.P., Chernyavskyi, V.V., Parunyan, L.M. |
| المصدر: | Clinical and Preventive Medicine; No 1 (2022): Clinical and Preventive Medicine; 11-20 ; Клиническая и профилактическая медицина; № 1 (2022): Clinical and Preventive Medicine; 11-20 ; Клінічна та профілактична медицина; № 1 (2022): Клінічна та профілактична медицина; 11-20 ; 2616-4868 |
| بيانات النشر: | Scientific and Practical Center of Preventive and Clinical Medicine |
| سنة النشر: | 2022 |
| المجموعة: | Clinical and Preventive Medicine (E-Journal) / Клінічна та профілактична медицина |
| مصطلحات موضوعية: | liver cirrhosis, atrial fibrillation, hemostasis, NPTEG, цироз печінки, фібриляція передсердь, гемостаз, НПТЕГ |
| الوصف: | The aim of this work. To evaluate and compare standard coagulation parameters and parameters of the low-frequency piezothromboelastography (LPTEG), global test of hemostasis assessment in patients with liver cirrhosis and atrial fibrillation before and after treatment with warfarin and dabigatran, as well as to determine the differences in parameters between patients of both groups. Material and methods. Stage I of the study was prospective, cross-sectional, II stage - randomized experimental study involving 70 patients (46 men and 22 women aged 42 to 83 years), who were divided at second stage into groups IA and received dabigatran at a dose of 110 mg 2g /d, and the IB group, who received warfarin at an initial dose of 5 mg for 3 months. Standard coagulation parameters and low-frequency piezothromboelastography data were assessed in comparison with treatment initiation and between groups. Statistical analysis was performed using the Excel for Windows software package and IBM SPSS Statistics. Results. After treatment with anticoagulant drugs, a statistically significant increase in the INR was revealed by 48.5% (p = 0.035), PT prolongation by 5.4% (p = 0.027) and thrombin time by 19.7% (p˂0.001) compared with initiation of treatment. Group IA showed a significant prolongation of APTT and TT parameters as compared to group IB (p˂0.01), while group IB had prolonged INR, PTI, PT and decreased fibrinogen levels (p˂0.05). According to the LPTEG data, in all patients, the t1 time was prolonged by 33.3%, the ICC index was decreased by 8% (p˂0.05), the CTA was decreased by 46% (p˂0.001), the coagulation time t3 was prolonged (p˂0.001) , parameters ICD, ICP, ITC, MA were significantly reduced by 26.7%, t5 was prolonged (p˂0.001), ICLR was reduced (p˂0.001) and CTAA was decreased by 10.3% (p˂0.001) compared with the beginning of treatment. Comparative analysis of IА and IB group of patients showed a statistically significant difference in all parameters of the LPTEG at the level of p˂0.001. Conclusions. Treatment with ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Ukrainian |
| Relation: | http://cp-medical.com/index.php/journal/article/view/190/162; http://cp-medical.com/index.php/journal/article/view/190 |
| DOI: | 10.31612/2616-4868.1(19).2022.02 |
| الاتاحة: | http://cp-medical.com/index.php/journal/article/view/190 https://doi.org/10.31612/2616-4868.1(19).2022.02 |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.62573765 |
| قاعدة البيانات: | BASE |
| DOI: | 10.31612/2616-4868.1(19).2022.02 |
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