التفاصيل البيبلوغرافية
| العنوان: |
DNA replication control: Liquid-liquid phase separation comes into play |
| المؤلفون: |
Nathanailidou, Patroula, Taraviras, Stavros, Lygerou, Zoi |
| المساهمون: |
State Scholarships Foundation (IKY), University of Patras |
| المصدر: |
Journal of Molecular Biochemistry; Vol 9, No 1 (2020) |
| بيانات النشر: |
Lorem Ipsum Press |
| سنة النشر: |
2021 |
| المجموعة: |
Journal of Molecular Biochemistry |
| مصطلحات موضوعية: |
DNA replication, phase separation, replication program, DNA replication licensing |
| الوصف: |
Liquid-liquid phase separation (LLPS) has been recently suggested as a new potential mechanism underpinning various organizational aspects of the cell, from the formation of sub-cellular, biomolecule enrichments to the assembly of organelles. In eukaryotes, DNA replication follows a strict temporal and spatial program that is majorly affected by the chromatin structure, the nuclear organization and the availability of limiting initiation factors, however the regulatory mechanisms driving the process have not been fully elucidated. Original data published lately revealed for the first time that the components of the pre-replicative complex, ORC, Cdc6 and Cdt1, are able to phase separate indicating a possible connection between LLPS and DNA replication. Here, we critically present these preliminary data and propose mechanistic models that could support this regulatory link and lead to new future research directions. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
http://www.jmolbiochem.com/index.php/JmolBiochem/article/view/268/168; http://www.jmolbiochem.com/index.php/JmolBiochem/article/view/268 |
| الاتاحة: |
http://www.jmolbiochem.com/index.php/JmolBiochem/article/view/268 |
| Rights: |
Articles will be published under the terms of the Creative Commons Attribution License allowing unrestricted copying, distribution, transmission and adaptation of the work, under the condition that the original article is properly cited.More specifically, authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). |
| رقم الانضمام: |
edsbas.6250891B |
| قاعدة البيانات: |
BASE |