التفاصيل البيبلوغرافية
| العنوان: |
Archetypal analysis for visual field loss characterization of leber hereditary optic neuropathy |
| المؤلفون: |
Coutinho, Catarina, Zanchetta, Ferdinando, Carbonelli, Michele, Galzignato, Alice, Battista, Marco, Fantaguzzi, Federico, Amore, Giulia, Carelli, Valerio, Brotto, Luigi, Nucci, Paolo, Checchin, Lisa, Savini, Giacomo, Bandello, Francesco, La Morgia, Chiara, Cascavilla, Maria Lucia, Fioresi, Rita, Barboni, Piero |
| المصدر: |
Acta Ophthalmologica ; volume 103, issue S284 ; ISSN 1755-375X 1755-3768 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2025 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Aims/Purpose: Characterization of Visual Field (VF) loss patterns of chronic stage Leber Hereditary Optic Neuropathy (LHON) patients by application of machine learning (ML). Methods: For chronic stable LHON patient, at least 2 years after disease onset, 24‐2 and 30‐2 VFs tests performed by SITA standard Humphrey VF analyzer (Carl Zeiss Meditec) were collected. Two groups were considered: with visual acuity (VA) recovery, when a change of more than 0.2 decimal or from off‐chart to on‐chart vision after initial loss of vision; and without VA recovery. Resorting to Python, archetypal analysis (AA) was implemented to each group using the VFs total deviations (TDs). Spearman correlations were performed between each archetype (AT) relative weight and the VFs mean deviation (MD). Results: From 117 patients (203 eyes), 104 VFs made up the Recovered Group, and 115 VFs the Not Recovered Group. Both AA models were made up of 7 ATs. For the Recovered Group, the normal VF AT had the highest weight (33.40%), followed by different severity central scotoma ATs (AT2, 16.32%; AT3, 11.82%; AT5, 10.37%). For the Non‐Recovered Group, first the widespread loss AT (47.87%), followed by enlarged central scotoma ATs (AT2, 11.13%; AT5, 8.97%). For the Recovered Group, AT3 (Cecocentral Scotoma), AT4 (Fenestration) and AT6 (Widespread loss) weights decreased with increasing MD; and AT1 (normal VF) and AT5 (Central Scotoma) increased with increasing MD. The AT1 (Widespread Loss) weight of the Non‐Recovered Group decreased with increasing MD, while AT5 (Enlarged Central Scotoma) weight increased with increasing MD. Conclusions: Implementation of AA‐ML allowed the association of more severe and widespread visual loss patterns to LHON patients without visual recovery, whereas less severe and more centralized patterns to recovered patients, as expected. Therefore, the presented VF analysis might present as a standardized method for LHON visual loss characterization, providing further characterization of patients with and without vision recovery. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/aos.17183 |
| الاتاحة: |
https://doi.org/10.1111/aos.17183 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: |
edsbas.6238D40A |
| قاعدة البيانات: |
BASE |