Academic Journal
Re-polarisation of Macrophages Within Collective Tumour Cell Migration: A Multiscale Moving Boundary Approach
| العنوان: | Re-polarisation of Macrophages Within Collective Tumour Cell Migration: A Multiscale Moving Boundary Approach |
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| المؤلفون: | Suveges, Szabolcs, Eftimie, Raluca, Trucu, Dumitru |
| المصدر: | Frontiers in Applied Mathematics and Statistics ; volume 7 ; ISSN 2297-4687 |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2022 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Cancer invasion of the surrounding tissue is a multiscale process of collective cell movement that involves not only tumour cells but also other immune cells in the environment, such as the tumour-associated macrophages (TAMs). The heterogeneity of these immune cells, with the two extremes being the pro-inflammatory and anti-tumour M1 cells, and the anti-inflammatory and pro-tumour M2 cells, has a significant impact on cancer invasion as these cells interact in different ways with the tumour cells and with the ExtraCellular Matrix (ECM). Experimental studies have shown that cancer cells co-migrate with TAMs, but the impact of these different TAM sub-populations (which can change their phenotype and re-polarise depending on the microenvironment) on this co-migration is not fully understood. In this study, we extend a previous multi-scale moving boundary mathematical model, by introducing the M1-like macrophages alongside with their exerted multi-scale effects on the tumour invasion process. With the help of this model we investigate numerically the impact of re-polarising the M2 TAMs into the anti-tumoral M1 phenotype and how such a strategy affects the overall tumour progression. In particular, we investigate numerically whether the M2→M1 re-polarisation could depend on time and/or space, and what would be the macroscopic effects of this spatial- and temporal-dependent re-polarisation on tumour invasion. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fams.2021.799650 |
| DOI: | 10.3389/fams.2021.799650/full |
| الاتاحة: | http://dx.doi.org/10.3389/fams.2021.799650 https://www.frontiersin.org/articles/10.3389/fams.2021.799650/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.623785C1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fams.2021.799650 |
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