Academic Journal
The N-terminus of rodent and human MAD1 confers species-specific stringency to spindle assembly checkpoint
| العنوان: | The N-terminus of rodent and human MAD1 confers species-specific stringency to spindle assembly checkpoint |
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| المؤلفون: | Peloponese, Jean-Marie, Haller, V, Kibler, V, Kasai, T, Chi, Y-H, Peloponese, J-M, Yedavalli, V, Jeang, K-T, Haller, K, Kibler, K, Kasai, K, Yedavalli, K |
| المساهمون: | Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 0950-9232. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2006 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology |
| الوصف: | International audience ; The spindle assembly checkpoint (SAC) guards against chromosomal mis-segregation and the emergence of aneuploidy. SAC in higher eukaryotes includes at least 10 proteins including MAD1-3, BUB1-3, and Msp1. A long-standing observation has been that rodent cells are more tolerant of microtubule toxins than primate cells indicating that SAC function is more relaxed in the former than the latter. Here, we report on an unexpected functional difference between the rodent and human MAD1 component of the respective SAC. Ectopic expression of human MAD1 in mouse and hamster cells corrected a relaxed SAC to a more stringent form. Our findings posit MAD1 as a species-specific determinant which influences the stringency of cellular response to microtubule depolymerization and spindle damage. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/16288203; hal-02137894; https://hal.science/hal-02137894; PUBMED: 16288203 |
| DOI: | 10.1038/sj.onc.1209259 |
| الاتاحة: | https://hal.science/hal-02137894 https://doi.org/10.1038/sj.onc.1209259 |
| رقم الانضمام: | edsbas.61EAF21D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/sj.onc.1209259 |
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