Academic Journal
Pain tolerance after stroke: The Tromsø study
| العنوان: | Pain tolerance after stroke: The Tromsø study |
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| المؤلفون: | Melum, Tonje Anita, Årnes, Anders, Stigum, Hein, Stubhaug, Audun, Steingrímsdóttir, Ólöf Anna, Mathiesen, Ellisiv B., Nielsen, Christopher Sivert |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | University of Tromsø: Munin Open Research Archive |
| الوصف: | Background: Stroke lesions might alter pain processing and modulation by affecting the widely distributed network of brain regions involved. We aimed to compare pain tolerance in stroke survivors and stroke-free persons in the general population, with and without chronic pain. Methods: We included all participants of the sixth and seventh wave of the population-based Tromsø Study who had been tested with the cold pressor test (hand in cold water bath, 3°C, maximum time 106 s in the sixth wave and 120 s in the seventh) and who had information on previous stroke status and covariates. Data on stroke status were obtained from the Tromsø Study Cardiovascular Disease Register and the Norwegian Stroke Register. Cox regression models were fitted using stroke prior to study attendance as the independent variable, cold pressor endurance time as time variable and hand withdrawal from cold water as event. Statistical adjustments were made for age, sex, diabetes, hypertension, hyperlipidaemia, body mass index and smoking. Results: In total 21,837 participants were included, 311 of them with previous stroke. Stroke was associated with decreased cold pain tolerance time, with 28% increased hazard of hand withdrawal (hazard ratio [HR] 1.28, 95% CI 1.10–1.50). The effect was similar in participants with (HR 1.28, 95% CI 0.99–1.66) and without chronic pain (HR 1.29, 95% CI 1.04–1.59). Conclusions: Stroke survivors, with and without chronic pain, had lower cold pressor pain tolerance, with possible clinical implications for pain in this group. Significance: We found lower pain tolerance in participants with previous stroke compared to stroke-free participants of a large, population-based study. The association was present both in those with and without chronic pain. The results may warrant increased awareness by health professionals towards pain experienced by stroke patients in response to injuries, diseases and procedures. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1090-3801 1532-2149 |
| Relation: | Melum, T.A. (2024). Aspects of brain health and pain tolerance in a general population. (Doctoral thesis). https://hdl.handle.net/10037/32830; European Journal of Pain; info:eu-repo/grantAgreement/EC/H2020/848099/Jurisdiction/EU/Molecular Mechanisms Associating Chronic Pain with Fatigue, Affective Disorders, Cardiovascular Disease and Total Comorbidity/PainFACT/; Melum, Årnes, Stigum, Stubhaug, Steingrímsdóttir, Mathiesen, Nielsen. Pain tolerance after stroke: The Tromsø study. European Journal of Pain. 2023; FRIDAID 2152674; https://hdl.handle.net/10037/31086 |
| DOI: | 10.1002/ejp.2124 |
| الاتاحة: | https://hdl.handle.net/10037/31086 https://doi.org/10.1002/ejp.2124 |
| Rights: | Attribution 4.0 International (CC BY 4.0) ; openAccess ; Copyright 2023 The Author(s) ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.61AC395C |
| قاعدة البيانات: | BASE |
| تدمد: | 10903801 15322149 |
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| DOI: | 10.1002/ejp.2124 |