Academic Journal
Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR–/–and LDLR+/+mice
| العنوان: | Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR–/–and LDLR+/+mice |
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| المؤلفون: | Carroll, Sean, Hobkirk, James, Browning, Michael J., Janus, Justyna, Kheder, Ramiar, Saeed, Zeayd, Stover, Cordula |
| بيانات النشر: | Wiley |
| سنة النشر: | 2017 |
| المجموعة: | University of Hull: Repository@Hull |
| مصطلحات موضوعية: | Diet, Metabolic syndrome, Mouse study, Vitamin D |
| الوصف: | © 2017 The Authors. Immunity, Inflammation and Disease Published by John Wiley & Sons Ltd. INTRODUCTION: Fatty liver disease is prevalent in populations with high caloric intake. Nutritherapeutic approaches are being considered, such as supplementary Vitamin D 3 , to improve aspects of metabolic syndrome, namely fatty liver disease, hyperlipidemia, and insulin resistance associated with obesity. METHODS: We analyzed female LDLR -/- and LDLR +/+ mice on a 10-week diabetogenic diet for markers of fatty liver disease, metabolic strain, and inflammation. RESULTS: The groups on a high fat high sugar diet with supplementary Vitamin D 3 , in comparison with the groups on a high fat high sugar diet alone, showed improved transaminase levels, significantly less hypertriglyceridemia and hyperinsulinemia, and histologically, there was less pericentral hepatic steatosis. Levels of non-esterified fatty acids and lipid peroxidation products were significantly lower in the group supplemented with additional Vitamin D 3 , as were systemic markers of inflammation (serum endotoxin and IL-6). M2 macrophage phenotype predominated in the group supplemented with additional Vitamin D 3 . Beneficial changes were observed as early as five weeks’ supplementation with Vitamin D 3 and extended to restoration of high fat high sugar diet induced decrease of bone mineral density. CONCLUSION: In summary, Vitamin D 3 was a significantly beneficial dietary additive to blunt a prediabetic phenotype in diet-induced obesity of female LDLR -/- and LDLR +/+ mice. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://hull-repository.worktribe.com/output/450554; Immunity, inflammation and disease; Volume 5; Issue 2; Pagination 151-154; https://hull-repository.worktribe.com/file/450554/1/Kheder_et_al-2017-Immunity,_Inflammation_and_Disease.pdf |
| DOI: | 10.1002/iid3.154 |
| الاتاحة: | https://hull-repository.worktribe.com/file/450554/1/Kheder_et_al-2017-Immunity,_Inflammation_and_Disease.pdf https://hull-repository.worktribe.com/output/450554 https://doi.org/10.1002/iid3.154 |
| Rights: | openAccess |
| رقم الانضمام: | edsbas.6152B2B9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/iid3.154 |
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