التفاصيل البيبلوغرافية
| العنوان: |
Relative versus absolute change in forced vital capacity in idiopathic pulmonary fibrosis |
| المؤلفون: |
Richeldi, L., Ryerson, C.J., Lee, J.S., Wolters, P.J., Koth, L.L., Ley, B., Elicker, B.M., Jones, K.D., King, T.E. Jr, Ryu, JH, Collard, H.R. |
| سنة النشر: |
2012 |
| المجموعة: |
University of Southampton: e-Prints Soton |
| الوصف: |
BACKGROUND: Decline in forced vital capacity (FVC) over time reliably predicts mortality in patients with idiopathic pulmonary fibrosis. The use of this measure in clinical practice is recommended by current evidence-based guidelines. It is unknown if the method of calculating decline in FVC (relative vs. absolute change) impacts its frequency or its ability to predict mortality. METHODS: Patients with idiopathic pulmonary fibrosis from two prospective cohorts were included if they had a baseline and 12-month follow-up FVC. A ?10% decline in FVC from baseline was calculated in two ways: a relative decline of 10% (e.g., from 60% predicted to 54% predicted) and an absolute decline of 10% (e.g., from 60% predicted to 50% predicted). The frequency of a ?10% decline in FVC and its ability to predict 2-year transplant-free survival were compared between these two methods. Declines in FVC of ?5% and ?15% were similarly compared. Analyses were performed unadjusted and adjusted for age, gender, use of oxygen, baseline FVC and baseline diffusion capacity for carbon monoxide. RESULTS: The frequency of any given FVC decline was significantly greater using the relative change in FVC method. For ?10% decline, both methods predicted 2-year transplant-free survival with similar accuracy, and remained significant predictors after adjusting for baseline characteristics. The absolute change method appeared more predictive for ?5% decline. CONCLUSIONS: Using the relative change in FVC maximises the chance of identifying a ?10% decline in FVC without sacrificing prognostic accuracy. This may not hold true for ?5% decline in FVC. These findings have important implications for clinical practice and the design of clinical trials. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
Richeldi, L., Ryerson, C.J., Lee, J.S., Wolters, P.J., Koth, L.L., Ley, B., Elicker, B.M., Jones, K.D., King, T.E. Jr, Ryu, JH and Collard, H.R. (2012) Relative versus absolute change in forced vital capacity in idiopathic pulmonary fibrosis. Thorax, 67 (5), 407-411. (doi:10.1136/thoraxjnl-2011-201184 ). (PMID:22426899 ) |
| الاتاحة: |
https://eprints.soton.ac.uk/353516/ |
| رقم الانضمام: |
edsbas.614D91E5 |
| قاعدة البيانات: |
BASE |