Academic Journal
The novel dehydroepiandrosterone derivative BNN27 counteracts the impairing effects of anesthetic ketamine on rats’ non-spatial and spatial recognition memory
| العنوان: | The novel dehydroepiandrosterone derivative BNN27 counteracts the impairing effects of anesthetic ketamine on rats’ non-spatial and spatial recognition memory |
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| المؤلفون: | Pitsikas N., Zoupa E., Gravanis A. |
| المصدر: | Behavioural Brain Research ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85131559094&doi=10.1016%2fj.bbr.2022.113937&partnerID=40&md5=17dd459f623c2a3479a1f8f2f990a025 |
| سنة النشر: | 2022 |
| المجموعة: | University of Thessaly Institutional Repository / Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας |
| مصطلحات موضوعية: | bnn 27, ketamine, prasterone, unclassified drug, 3beta21 dihydroxy 20 epoxy 5 pregnene, anesthetic agent, animal experiment, animal model, antioxidant activity, Article, behavior assessment, cognition assessment, controlled study, drug synthesis, locomotion, male, memory disorder, motor performance, nonhuman, novel object recognition test, randomized controlled trial, rat, recognition, task performance, animal, physiology, Wistar rat, Anesthetics, Animals, Dehydroepiandrosterone |
| الوصف: | Conspicuous experimental evidence indicates that anesthetic doses of the non-competitive NMDA receptor antagonist ketamine disrupt memory abilities in rodents. BNN27 is a synthetic analogue of dehydroepiandrosterone (DHEA) with potent antioxidant properties and its involvement in cognition has recently been shown. It is not yet clarified whether BNN27 can attenuate the cognition deficits induced by anesthetic ketamine. The present study was designed to elucidate this issue in the rat. For this purpose, the object recognition and the object location tests which are behavioral procedures evaluating non-spatial and spatial recognition memory respectively in rodents were used. The effects of compounds on motility were also tested utilizing a motor activity cage. Post-training administration of BNN27 (3 and 6 mg/kg, intraperitoneally) counteracted anesthetic ketamine (100 mg/kg, intraperitoneally)-induced non-spatial and spatial recognition memory deficits. Further, these effects cannot be attributed to changes to locomotor activity. Our findings clearly show the protective role of BNN27, on recognition memory impairment induced by anesthetic ketamine, indicating a functional interaction following co-administration of synthetic microneurotrophins and ketamine. © 2022 Elsevier B.V. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 01664328 |
| Relation: | http://hdl.handle.net/11615/78256 |
| DOI: | 10.1016/j.bbr.2022.113937 |
| الاتاحة: | http://hdl.handle.net/11615/78256 https://doi.org/10.1016/j.bbr.2022.113937 |
| رقم الانضمام: | edsbas.611C0FB6 |
| قاعدة البيانات: | BASE |
| تدمد: | 01664328 |
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| DOI: | 10.1016/j.bbr.2022.113937 |