Academic Journal
Immunotherapy in breast cancer patients: A focus on the use of the currently available biomarkers in oncology
| العنوان: | Immunotherapy in breast cancer patients: A focus on the use of the currently available biomarkers in oncology |
|---|---|
| المؤلفون: | Criscitiello C, Guerini-Rocco E, Viale G, Fumagalli C, Sajjadi E, Venetis K, Piciotti R, Invernizzi M, Malapelle U, Fusco N |
| المساهمون: | C. Criscitiello, E. Guerini-Rocco, G. Viale, C. Fumagalli, E. Sajjadi, K. Veneti, R. Piciotti, M. Invernizzi, U. Malapelle, N. Fusco |
| سنة النشر: | 2021 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | breast cancer, biomarker, immunotherapy, TIL, PD-L1, mismatch repair, microsatellite instability, tumor mutational burden, Settore MED/08 - Anatomia Patologica, Settore MED/06 - Oncologia Medica |
| الوصف: | Immune checkpoint inhibitors (ICIs) have remarkably modified the way solid tumors are managed, including breast cancer. Unfortunately, only a relatively small number of breast cancer patients significantly respond to these treatments. To maximize the immunotherapy benefit in breast cancer, several efforts are currently being put forward for the identification of i) the best therapeutic strategy (i.e. ICI monotherapy or in association with chemotherapy, radiotherapy, or other drugs); ii) the optimal timing for administration (e.g. early/advanced stage of disease; adjuvant/neoadjuvant setting); iii) the most effective and reliable predictive biomarkers of response (e.g. tumor-infiltrating lymphocytes, programmed death-ligand 1, microsatellite instability associated with mismatch repair deficiency, and tumor mutational burden). In this article, we review the impacts and gaps in the characterization of immune-related biomarkers raised by clinical and translational research studies with immunotherapy treatments. Particular emphasis has been put on the documented evidence of significant clinical benefits of ICI in different randomized clinical trials, along with preanalytical and analytical issues in predictive biomarkers pathological assessment. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | numberofpages:37; http://hdl.handle.net/2434/842332; https://ssrn.com/abstract=3842070 |
| الاتاحة: | http://hdl.handle.net/2434/842332 https://ssrn.com/abstract=3842070 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.610DC5EC |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |