Academic Journal
Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections.
| العنوان: | Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections. |
|---|---|
| المؤلفون: | Heinonen, T., Ciarlo, E., Théroude, C., Pelekanou, A., Herderschee, J., Le Roy, D., Roger, T. |
| المصدر: | Frontiers in immunology, vol. 9, pp. 2675 |
| سنة النشر: | 2018 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Animals, Bacteria/immunology, Bacterial Infections/genetics, Bacterial Infections/immunology, Immunity, Innate, Mice, Knockout, Sirtuins/deficiency, Sirtuins/immunology, cytokine, endotoxemia, histone deacetylase, innate immunity, macrophage, metabolism, sepsis, sirtuin |
| الوصف: | Sirtuin 5 (SIRT5) is a member of the family of NAD + -dependent lysine/histone deacetylases. SIRT5 resides mainly in the mitochondria where it catalyzes deacetylation, demalonylation, desuccinylation, and deglutarylation of lysine to regulate metabolic and oxidative stress response pathways. Pharmacologic inhibitors of SIRT5 are under development for oncologic conditions, but nothing is known about the impact of SIRT5 on antimicrobial innate immune defenses. Using SIRT5 knockout mice, we show that SIRT5 deficiency does not affect immune cell development, cytokine production and proliferation by macrophages and splenocytes exposed to microbial and immunological stimuli. Moreover, preclinical models suggest that SIRT5 deficiency does not worsen endotoxemia, Klebsiella pneumoniae and Streptococcus pneumoniae pneumonia, Escherichia coli peritonitis, listeriosis, and staphylococcal infection. Altogether, these data support the safety profile in terms of susceptibility to infections of SIRT5 inhibitors under development. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/30515162; info:eu-repo/semantics/altIdentifier/eissn/1664-3224; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_39701912842C5; https://serval.unil.ch/notice/serval:BIB_39701912842C; https://serval.unil.ch/resource/serval:BIB_39701912842C.P001/REF.pdf |
| DOI: | 10.3389/fimmu.2018.02675 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_39701912842C https://doi.org/10.3389/fimmu.2018.02675 https://serval.unil.ch/resource/serval:BIB_39701912842C.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_39701912842C5 |
| Rights: | info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.610C4D19 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fimmu.2018.02675 |
|---|