Academic Journal
Non‐small cell lung carcinoma with focal coexpression of thyroid transcription factor‐1 and Δ Np63/p40: A case report
| العنوان: | Non‐small cell lung carcinoma with focal coexpression of thyroid transcription factor‐1 and Δ Np63/p40: A case report |
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| المؤلفون: | Terada, Kazuhiro, Menju, Toshi, Date, Horoshi, Haga, Hironori, Yoshizawa, Akihiko |
| المصدر: | Thoracic Cancer ; volume 15, issue 12, page 1029-1033 ; ISSN 1759-7706 1759-7714 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Most lung carcinomas are subtyped by their morphologies; however, immunohistochemistry is usually performed when it is difficult to determine. The most reliable antibodies for distinguishing lung adenocarcinoma from squamous cell carcinoma are thyroid transcription factor‐1 (TTF‐1) and p40 (ΔNp63). In general, these markers are mutually exclusive in their expression of lung primary carcinoma; however, a few cases of non‐small cell lung carcinoma (NSCLC) with coexpression of both markers have been reported. Examining a tissue microarray of 229 squamous cell carcinomas and 346 adenocarcinomas, we found one case of NSCLC with coexpression of TTF‐1 and p40. Herein, we present a 71‐year‐old man, who had a mass lesion in the left lung apex. A transbronchial lung biopsy was performed, revealing NSCLC. He underwent left upper segmentectomy and lymph node dissection. Macroscopically, the mass showed a white‐to‐tan solid tumor on the cut surface. Microscopically, the tumor was composed of polygonal tumor cells which had round and vesicular nuclei with prominent nucleoli. They had an abundant amount of cytoplasm, which was slightly eosinophilic or amphophilic. Multinucleated cells with atypical nuclear features were observed to be scattered in some areas. Multifocal necrosis and hemorrhage were also noted. Distinct squamous features and obvious glandular features were absent. Immunohistochemically, the most tumor cells were coexpressed positive for both TTF‐1 and p40. In our study, NSCLC with TTF‐1 and p40 coexpression is rare; therefore, it is necessary to obtain further data and examine similar cases to establish more precise definitions and clinicopathological features. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/1759-7714.15271 |
| الاتاحة: | http://dx.doi.org/10.1111/1759-7714.15271 https://onlinelibrary.wiley.com/doi/pdf/10.1111/1759-7714.15271 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.60F989F0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/1759-7714.15271 |
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