Academic Journal
Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments
| العنوان: | Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments |
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| المؤلفون: | Yiming Pang, Jianjun Jiang, Kexin Li, Lailai Yan, Yanqiu Feng, Junli Wang, Xiaolu Cao, Zhiwen Li, Bin Wang |
| المصدر: | International Journal of Environmental Research and Public Health, Vol 18, Iss 9836, p 9836 (2021) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | rare earth elements, hair, blood pressure, biomarker, oxidative stress, Medicine |
| الوصف: | Solid fuel combustion is an important source of the release of rare earth elements ( REEs ) into the ambient environment, resulting in potential adverse effects on human cardiovascular health. Our study aimed to identify reliable exposure biomarkers of REE intake and their potential role in blood pressure change. A total of 24 rats were administered with 14 REE chlorides at four doses (six rats per group). Fur samples were collected both before and after administration. Blood samples were collected after 12 weeks of REE intake. The REE concentrations in rat fur and blood samples were measured by inductively coupled plasma mass spectrometry. For each week, blood pressure, as well as heart rate and pulse pressure, were measured. The linear mixed-effect model was used to analyze the relationship between REE administration dose and blood pressure change. We found that the REE concentration in fur, but not blood, samples exhibited significant dose–response relationships with administration dose. It suggested that hair samples are a more efficient matrix for indicating the exposure level of a population to REEs than blood samples. However, there was no dose–response relationships between the administration dose and blood pressure change of rats, or with heart rate and pulse pressure for the 14 REEs . We also did not find a dose–response relationship between REE administration levels and plasma concentration of 8-hydroxy-2’-deoxyguanosine, as an important DNA oxidative stress damage biomarker. In conclusion, hair samples are more suitable as a sample type to reliably assess exposure to REEs than blood samples, and REEs did not have a direct adverse effect on blood pressure in our rat model. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1660-4601 1661-7827 |
| Relation: | https://www.mdpi.com/1660-4601/18/18/9836; https://doaj.org/toc/1661-7827; https://doaj.org/toc/1660-4601; https://doaj.org/article/7930b2d6575c475a9f909f8e652c7c8a |
| DOI: | 10.3390/ijerph18189836 |
| الاتاحة: | https://doi.org/10.3390/ijerph18189836 https://doaj.org/article/7930b2d6575c475a9f909f8e652c7c8a |
| رقم الانضمام: | edsbas.60931119 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16604601 16617827 |
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| DOI: | 10.3390/ijerph18189836 |