Academic Journal
Mesenchymal Stromal Cell Secretome for the Treatment of Immune-Mediated Inflammatory Diseases: Latest Trends in Isolation, Content Optimization and Delivery Avenues
| العنوان: | Mesenchymal Stromal Cell Secretome for the Treatment of Immune-Mediated Inflammatory Diseases: Latest Trends in Isolation, Content Optimization and Delivery Avenues |
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| المؤلفون: | Muñoz Pérez, Elena, González Pujana, Ainhoa, Igartua Olaechea, Manuela, Santos Vizcaíno, Edorta, Hernández Martín, Rosa María |
| بيانات النشر: | MDPI |
| سنة النشر: | 2021 |
| المجموعة: | ADDI: Repositorio Institucional de la Universidad del País Vasco / Euskal Herriko Unibertsitatea (UPV/EHU - Basque Country University) |
| مصطلحات موضوعية: | MSCs, secretome, hydrogel, extracellular vesicles, exosomes, immunomodulation, MIDs, IBD, GvHD, OA |
| الوصف: | Considering the high prevalence and the complex pharmacological management of immune-mediated inflammatory diseases (IMIDs), the search for new therapeutic approaches for their treatment is vital. Although the immunomodulatory and anti-inflammatory effects of mesenchymal stromal cells (MSCs) have been extensively studied as a potential therapy in this field, direct MSC implantation presents some limitations that could slow down the clinical translation. Since the beneficial effects of MSCs have been mainly attributed to their ability to secrete a plethora of bioactive factors, their secretome has been proposed as a new and promising pathway for the treatment of IMIDs. Formed from soluble factors and extracellular vesicles (EVs), the MSC-derived secretome has been proven to elicit immunomodulatory effects that control the inflammatory processes that occur in IMIDs. This article aims to review the available knowledge on the MSC secretome, evaluating the advances in this field in terms of its composition, production and application, as well as analyzing the pending challenges in the field. Moreover, the latest research involving secretome administration in IMIDs is discussed to provide an updated state-of-the-art for this field. Finally, novel secretome delivery alternatives are reviewed, paying special attention to hydrogel encapsulation as one of the most convenient and promising strategies. ; This research was funded by the projects SAF2017-82292-R (MINECO), AEI/FEDER, UE, ICTS “NANBIOSIS” Drug Formulation Unit (U10) and the Basque Country Government (Grupos Consolidados, No ref: IT907-16). Elena Munoz-Perez thanks the Basque Government for the predoctoral grant (PRE_2020_1_0279). A. Gonzalez-Pujana thanks the University of the Basque Country (UPV/EHU) for the postdoctoral grant (ESPDOC20/119). |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1999-4923 |
| Relation: | info:eu-repo/grantAgreement/MINECO/SAF2017-82292-R; https://www.mdpi.com/1999-4923/13/11/1802/htm; Pharmaceutics 13(11) : (2021) // Article ID 1802; http://hdl.handle.net/10810/54245 |
| DOI: | 10.3390/pharmaceutics13111802 |
| الاتاحة: | http://hdl.handle.net/10810/54245 https://doi.org/10.3390/pharmaceutics13111802 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/3.0/es/ ; 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| رقم الانضمام: | edsbas.604A1B84 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19994923 |
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| DOI: | 10.3390/pharmaceutics13111802 |