Academic Journal
SARS-CoV-2 IgG seroprevalence surveys in blood donors before the vaccination campaign, France 2020-2021
| العنوان: | SARS-CoV-2 IgG seroprevalence surveys in blood donors before the vaccination campaign, France 2020-2021 |
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| المؤلفون: | Gallian, Pierre, Hozé, Nathanaël, Brisbarre, Nadège, Saba Villarroel, Paola Mariela, Nurtop, Elif, Isnard, Christine, Pastorino, Boris, Richard, Pascale, Morel, Pascal, Cauchemez, Simon, de Lamballerie, Xavier |
| المساهمون: | Etablissement Français du Sang La Plaine Saint-Denis (EFS), Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Etablissement Français du Sang Provence-Alpes Côte-d'Azur et Corse (EFS), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang Bourgogne-Franche-Comté (EFS BFC)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC), ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016) |
| المصدر: | EISSN: 2589-0042 ; iScience ; https://hal.science/hal-04007375 ; iScience, 2023, 26 (4), pp.106222. ⟨10.1016/j.isci.2023.106222⟩ |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Immune response, Immunology, Virology, [SDV]Life Sciences [q-bio], [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology |
| الوصف: | International audience ; We conducted a cross-sectional study for SARS-CoV-2 anti-S1 IgG prevalence in French blood donors (n=32605), from March-2020 to January-2021. A mathematical model combined seroprevalence with daily number of hospital admissions to estimate the probability of hospitalization upon infection and determine the number of infections while correcting for antibody decay. There was an overall seroprevalence increase over the study period and we estimate that ∼15% of the French population had been infected by SARS-CoV-2 by January-2021. The infection/hospitalization ratio increased with age, from 0.31% (18-30yo) to 4.5% (61-70yo). Half of the IgG-S1 positive individuals had no detectable antibodies 4 to 5 months after infection. The seroprevalence in group O donors (7.43%) was lower (p=0.003) than in A, B and AB donors (8.90%). We conclude, based on seroprevalence data and mathematical modelling, that a large proportion of the French population was unprotected against severe disease prior to the vaccination campaign. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36818722; hal-04007375; https://hal.science/hal-04007375; https://hal.science/hal-04007375/document; https://hal.science/hal-04007375/file/1main.pdf; PUBMED: 36818722; PUBMEDCENTRAL: PMC9930380 |
| DOI: | 10.1016/j.isci.2023.106222 |
| الاتاحة: | https://hal.science/hal-04007375 https://hal.science/hal-04007375/document https://hal.science/hal-04007375/file/1main.pdf https://doi.org/10.1016/j.isci.2023.106222 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.600B45A5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.isci.2023.106222 |
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