Academic Journal
A systematic review on omics data (metagenomics, metatranscriptomics, and metabolomics) in the role of microbiome in gallbladder disease
| العنوان: | A systematic review on omics data (metagenomics, metatranscriptomics, and metabolomics) in the role of microbiome in gallbladder disease |
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| المؤلفون: | Di Carlo, Paola, Serra, Nicola, Alduina, Rosa, Guarino, Riccardo, Craxì, Antonio, Giammanco, Anna, Fasciana, Teresa, Cascio, Antonio, Sergi, Consolato M |
| المساهمون: | Di Carlo, Paola, Serra, Nicola, Alduina, Rosa, Guarino, Riccardo, Craxì, Antonio, Giammanco, Anna, Fasciana, Teresa, Cascio, Antonio, Sergi, Consolato M |
| بيانات النشر: | FRONTIERS MEDIA SA |
| سنة النشر: | 2022 |
| المجموعة: | IRIS Università degli Studi di Palermo |
| مصطلحات موضوعية: | bile, cancer, gallbladder disease, human microbiota, taxonomy |
| الوصف: | Microbiotas are the range of microorganisms (mainly bacteria and fungi) colonizing multicellular, macroscopic organisms. They are crucial for several metabolic functions affecting the health of the host. However, difficulties hamper the investigation of microbiota composition in cultivating microorganisms in standard growth media. For this reason, our knowledge of microbiota can benefit from the analysis of microbial macromolecules (DNA, transcripts, proteins, or by-products) present in various samples collected from the host. Various omics technologies are used to obtain different data. Metagenomics provides a taxonomical profile of the sample. It can also be used to obtain potential functional information. At the same time, metatranscriptomics can characterize members of a microbiome responsible for specific functions and elucidate genes that drive the microbiotas relationship with its host. Thus, while microbiota refers to microorganisms living in a determined environment (taxonomy of microorganisms identified), microbiome refers to the microorganisms and their genes living in a determined environment and, of course, metagenomics focuses on the genes and collective functions of identified microorganisms. Metabolomics completes this framework by determining the metabolite fluxes and the products released into the environment. The gallbladder is a sac localized under the liver in the human body and is difficult to access for bile and tissue sampling. It concentrates the bile produced in the hepatocytes, which drains into bile canaliculi. Bile promotes fat digestion and is released from the gallbladder into the upper small intestine in response to food. Considered sterile originally, recent data indicate that bile microbiota is associated with the biliary tract's inflammation and carcinogenesis. The sample size is relevant for omic studies of rare diseases, such as gallbladder carcinoma. Although in its infancy, the study of the biliary microbiota has begun taking advantage of several omics strategies, mainly ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36111147; info:eu-repo/semantics/altIdentifier/wos/WOS:000874801700001; volume:13; numberofpages:14; journal:FRONTIERS IN PHYSIOLOGY; https://hdl.handle.net/10447/619318; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85138239696 |
| DOI: | 10.3389/fphys.2022.888233 |
| الاتاحة: | https://hdl.handle.net/10447/619318 https://doi.org/10.3389/fphys.2022.888233 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5FEF48C7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fphys.2022.888233 |
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