Academic Journal
Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair
| العنوان: | Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair |
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| المؤلفون: | Wang, Jingqiang, Liu, Chunye, He, Lingli, Xie, Zhiyao, Bai, Lanyue, Yu, Wentao, Wang, Zuoyun, Lu, Yi, Gao, Dong, Fu, Junfen, Zhang, Lei, Zeng, Yi Arial |
| المساهمون: | National Key Research and Development Program of China, National Natural Science Foundation of China, Chinese Academy of Sciences, Fundamental Research Funds for the Central Universities, China Postdoctoral Science Foundation, Zhejiang Provincial Preferential Postdoctoral Foundation, Postdoctoral Exchange Fellowship Program 2021 |
| المصدر: | eLife ; volume 11 ; ISSN 2050-084X |
| بيانات النشر: | eLife Sciences Publications, Ltd |
| سنة النشر: | 2022 |
| المجموعة: | eLife (E-Journal - via CrossRef) |
| الوصف: | Ovarian surface epithelium (OSE) undergoes recurring ovulatory rupture and OSE stem cells rapidly generate new cells for the repair. How the stem cell activation is triggered by the rupture and promptly turns on proliferation is unclear. Our previous study has identified that Protein C Receptor (Procr) marks OSE progenitors. In this study, we observed decreased adherent junction and selective activation of YAP signaling in Procr progenitors at OSE rupture site. OSE repair is impeded upon deletion of Yap1 in these progenitors. Interestingly, Procr+ progenitors show lower expression of Vgll4, an antagonist of YAP signaling. Overexpression of Vgll4 in Procr+ cells hampers OSE repair and progenitor proliferation, indicating that selective low Vgll4 expression in Procr+ progenitors is critical for OSE repair. In addition, YAP activation promotes transcription of the OSE stemness gene Procr . The combination of increased cell division and Procr expression leads to expansion of Procr+ progenitors surrounding the rupture site. These results illustrate a YAP-dependent mechanism by which the stem/progenitor cells recognize the murine ovulatory rupture, and rapidly multiply their numbers, highlighting a YAP-induced stem cell expansion strategy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.7554/elife.75449 |
| الاتاحة: | http://dx.doi.org/10.7554/elife.75449 https://cdn.elifesciences.org/articles/75449/elife-75449-v1.pdf https://cdn.elifesciences.org/articles/75449/elife-75449-v1.xml https://elifesciences.org/articles/75449 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ ; http://creativecommons.org/licenses/by/4.0/ ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.5FE9F0F0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7554/elife.75449 |
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