Academic Journal
Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging
| العنوان: | Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging |
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| المؤلفون: | Thaler, Christian, Kyselyova, Anna A, Faizy, Tobias D, Nawka, Marie T, Jespersen, Sune, Hansen, Brian, Stellmann, Jan-Patrick, Heesen, Christoph, Stürner, Klarissa H, Stark, Maria, Fiehler, Jens, Bester, Maxim, Gellißen, Susanne |
| المصدر: | Thaler , C , Kyselyova , A A , Faizy , T D , Nawka , M T , Jespersen , S , Hansen , B , Stellmann , J-P , Heesen , C , Stürner , K H , Stark , M , Fiehler , J , Bester , M & Gellißen , S 2021 , ' Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging ' , PLOS ONE , vol. 16 , no. 2 , e0245844 . https://doi.org/10.1371/journal.pone.0245844 |
| سنة النشر: | 2021 |
| المجموعة: | Aarhus University: Research |
| الوصف: | BACKGROUND: Mean kurtosis (MK), one of the parameters derived from diffusion kurtosis imaging (DKI), has shown increased sensitivity to tissue microstructure damage in several neurological disorders. METHODS: Thirty-seven patients with relapsing-remitting MS and eleven healthy controls (HC) received brain imaging on a 3T MR scanner, including a fast DKI sequence. MK and mean diffusivity (MD) were measured in the white matter of HC, normal-appearing white matter (NAWM) of MS patients, contrast-enhancing lesions (CE-L), FLAIR lesions (FLAIR-L) and black holes (BH). RESULTS: Overall 1529 lesions were analyzed, including 30 CE-L, 832 FLAIR-L and 667 BH. Highest MK values were obtained in the white matter of HC (0.814 ± 0.129), followed by NAWM (0.724 ± 0.137), CE-L (0.619 ± 0.096), FLAIR-L (0.565 ± 0.123) and BH (0.549 ± 0.12). Lowest MD values were obtained in the white matter of HC (0.747 ± 0.068 10-3mm2/sec), followed by NAWM (0.808 ± 0.163 10-3mm2/sec), CE-L (0.853 ± 0.211 10-3mm2/sec), BH (0.957 ± 0.304 10-3mm2/sec) and FLAIR-L (0.976 ± 0.35 10-3mm2/sec). While MK differed significantly between CE-L and non-enhancing lesions, MD did not. CONCLUSION: MK adds predictive value to differentiate between MS lesions and might provide further information about diffuse white matter injury and lesion microstructure. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://pure.au.dk/portal/da/publications/heterogeneity-of-multiple-sclerosis-lesions-in-fast-diffusional-kurtosis-imaging(904e9e31-630b-4895-b44c-eb505926a6dd).html |
| DOI: | 10.1371/journal.pone.0245844 |
| الاتاحة: | https://pure.au.dk/portal/da/publications/heterogeneity-of-multiple-sclerosis-lesions-in-fast-diffusional-kurtosis-imaging(904e9e31-630b-4895-b44c-eb505926a6dd).html https://doi.org/10.1371/journal.pone.0245844 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5FDDF001 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0245844 |
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