Academic Journal
Untailored vs. Gender- and Body-Mass-Index-Tailored Skeletal Muscle Mass Index (SMI) to Assess Sarcopenia in Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)
| العنوان: | Untailored vs. Gender- and Body-Mass-Index-Tailored Skeletal Muscle Mass Index (SMI) to Assess Sarcopenia in Advanced Head and Neck Squamous Cell Carcinoma (HNSCC) |
|---|---|
| المؤلفون: | Morelli, Cristina, Formica, Vincenzo, Bossi, Paolo, Rofei, Michela, Guerriero, Simona, Riondino, Silvia, Argirò, Renato, Pucci, Noemi, Cenci, Tonia, Savino, Luca, Rinaldi, Carla G, Garaci, Francesco, Orlandi, Augusto, D'Angelillo, Rolando M, Arkenau, Hendrik-Tobias, Roselli, Mario |
| المساهمون: | Morelli, C, Formica, V, Bossi, P, Rofei, M, Guerriero, S, Riondino, S, Argirò, R, Pucci, N, Cenci, T, Savino, L, Rinaldi, Cg, Garaci, F, Orlandi, A, D'Angelillo, Rm, Arkenau, H, Roselli, M |
| سنة النشر: | 2023 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | head and neck cancer, sarcopenia, skeletal muscle mass index, Settore MED/06 |
| الوصف: | (1) background: sarcopenia lasting >1 year might be considered a chronic condition in many HNSCC patients. CT-scan-derived skeletal muscle mass Index (SMI) is an established surrogate of sarcopenia; yet, the cut-off reported in the literature (literature-based, lb-SMI < 43.2) is mainly based on the risk of chemoradiotherapy-induced toxicity, and the optimal value to discriminate OS is under-investigated. (2) methods: the effect on OS of the lb-SMI cutoff was compared with an untailored OS-oriented SMI cutoff obtained in a cohort of consecutive advanced HNSCC patients treated with primary chemoradiotherapy, bio-chemotherapy or chemo-immunotherapy (cohort-specific, cs-SMI cutoff). gender- and BMI-tailored (gt-SMI and bt-SMI) cut-offs were also evaluated. cutoff values were identified by using the maximally selected rank statistics for OS. (3) results: In 115 HNSCC patients, the cs-SMI cutoff was 31.50, which was lower compared to the lb-SMI reported cut-off. the optimal cut-off separately determined in females, males, overweight and non-overweight patients were 46.02, 34.37, 27.32 and 34.73, respectively. gt-SMI categorization had the highest effect on survival (p < 0.0001); its prognostic value was independent of the treatment setting or the primary location and was retained in a multivariate cox-regression analysis for OS including other HNSCC-specific prognostic factors (p = 0.0004). (4) conclusions: a tailored SMI assessment would improve clinical management of sarcopenia in chemoradiotherapy-, bio-chemotherapy- or chemo-immunotherapy-treated HNSCC patients. gender-based SMI could be used for prognostication in HNSCC patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37835410; info:eu-repo/semantics/altIdentifier/wos/WOS:001084987200001; volume:15; issue:19; firstpage:4716; journal:CANCERS; https://hdl.handle.net/2108/342905; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85174154970 |
| DOI: | 10.3390/cancers15194716 |
| الاتاحة: | https://hdl.handle.net/2108/342905 https://doi.org/10.3390/cancers15194716 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5F999251 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers15194716 |
|---|