Academic Journal
Palliative Electrochemotherapy in Vulvar Carcinoma: Preliminary Results of the ELECHTRA (Electrochemotherapy Vulvar Cancer) Multicenter Study
| العنوان: | Palliative Electrochemotherapy in Vulvar Carcinoma: Preliminary Results of the ELECHTRA (Electrochemotherapy Vulvar Cancer) Multicenter Study |
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| المؤلفون: | Perrone AM, Galuppi A, PIROVANO, CHIARA LUISA, Borghese G, Covarelli P, De Terlizzi F, Ferioli M, Cara S, Morganti AG, De Iaco P. |
| المساهمون: | Perrone AM, Galuppi A, Pirovano C, Borghese G, Covarelli P, De Terlizzi F, Ferioli M, Cara S, Morganti AG, De Iaco P. |
| سنة النشر: | 2019 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | bleomycin, electrochemotherapy, palliative therapy, recurrence, vulvar cancer |
| الوصف: | Vulvar cancer (VC) is a rare disease of which recurrence poses management problems due to patients’ advanced age and comorbidities, and to the localization of the disease. Palliative treatments, allowing local disease control in patients previously treated with multimodal therapies or with comorbidities, are lacking. In this study we tested electrochemotherapy (ECT) on recurrent VC refractory to standard therapies to assess the tumor response and to define the selection criteria for patient’s candidate to ECT. This is a multicenter observational study carried out in five Italian centers. Data about patients and tumor characteristics, treatment, toxicity, and clinical response were recorded. In all procedures, intravenous bleomycin was administered according to European Standard Operative Procedure ECT (ESOPE) guidelines. Sixty-one patients, with a median age 79 years (range: 39–85) and mainly affected by squamous cellular carcinoma (91.8%), were treated with ECT. No serious adverse events were reported. Patients were discharged after three days (median, range: 0–8 days). Two months after ECT, the clinical response rate was 83.6% and was not related to age, body mass index, International Federation of Gynecology and Obstetrics (FIGO) stage, number of treated nodules, or previous treatments. ECT is a safe procedure with a favorable cost-effectiveness ratio and should be considered as a treatment option for local disease control in patients unsuitable for standard therapies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31083599; info:eu-repo/semantics/altIdentifier/wos/WOS:000472738300070; volume:11; issue:5; firstpage:E657; lastpage:E657; numberofpages:10; journal:CANCERS; http://hdl.handle.net/11585/697795; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85066974024; https://www.mdpi.com/2072-6694/11/5/657/htm |
| DOI: | 10.3390/cancers11050657 |
| الاتاحة: | http://hdl.handle.net/11585/697795 https://doi.org/10.3390/cancers11050657 https://www.mdpi.com/2072-6694/11/5/657/htm |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5F7E4C3A |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers11050657 |
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