Academic Journal
Role of Hedgehog Signaling in Vasculature Development, Differentiation, and Maintenance
| العنوان: | Role of Hedgehog Signaling in Vasculature Development, Differentiation, and Maintenance |
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| المؤلفون: | Chapouly, Candice, Guimbal, Sarah, Hollier, Pierre-Louis, Renault, Marie-Ange |
| المساهمون: | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases, Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 1661-6596. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2019 |
| المجموعة: | Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| مصطلحات موضوعية: | Hedgehog, angiogenesis, blood–brain barrier, endothelium, vasculogenesis, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system |
| الوصف: | International audience ; The role of Hedgehog (Hh) signaling in vascular biology has first been highlighted in embryos by Pepicelli et al. in 1998 and Rowitch et al. in 1999. Since then, the proangiogenic role of the Hh ligands has been confirmed in adults, especially under pathologic conditions. More recently, the Hh signaling has been proposed to improve vascular integrity especially at the blood-brain barrier (BBB). However, molecular and cellular mechanisms underlying the role of the Hh signaling in vascular biology remain poorly understood and conflicting results have been reported. As a matter of fact, in several settings, it is currently not clear whether Hh ligands promote vessel integrity and quiescence or destabilize vessels to promote angiogenesis. The present review relates the current knowledge regarding the role of the Hh signaling in vasculature development, maturation and maintenance, discusses the underlying proposed mechanisms and highlights controversial data which may serve as a guideline for future research. Most importantly, fully understanding such mechanisms is critical for the development of safe and efficient therapies to target the Hh signaling in both cancer and cardiovascular/cerebrovascular diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31238510; inserm-02467649; https://inserm.hal.science/inserm-02467649; https://inserm.hal.science/inserm-02467649/document; https://inserm.hal.science/inserm-02467649/file/ijms-20-03076.pdf; PUBMED: 31238510; PUBMEDCENTRAL: PMC6627637 |
| DOI: | 10.3390/ijms20123076 |
| الاتاحة: | https://inserm.hal.science/inserm-02467649 https://inserm.hal.science/inserm-02467649/document https://inserm.hal.science/inserm-02467649/file/ijms-20-03076.pdf https://doi.org/10.3390/ijms20123076 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.5F7BB32E |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms20123076 |
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