Academic Journal
Procalcitonin is a predictor for high-grade vesicoureteral reflux in children: Meta-analysis of individual patient data
| العنوان: | Procalcitonin is a predictor for high-grade vesicoureteral reflux in children: Meta-analysis of individual patient data |
|---|---|
| المؤلفون: | Leroy, Sandrine, Romanello, Carla, Galetto-Lacour, Annick, Bouissou, François, Fernandez-Lopez, Anna, Smolkin, Vladislav, Gurgoz, Metin K., Bressan, Silvia, Karavanaki, Kyriaki, Tuerlinckx, David, Leblond, P., Pecile, Pierre, Coulais, Yvon, Cubells, Carlos, Halevy, Raphael, Aygun, A. Denizmen, Da Dalt, Liliana, Stefanidis, Constantinos J., Vander Borght, Thierry, Bigot, Sandra, Dubos, François, Gervaix, Alain, Chalumeau, Martin |
| المساهمون: | UCL - (MGD) Service de médecine nucléaire, UCL - (MGD) Service de pédiatrie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique |
| المصدر: | Journal of Pediatrics, Vol. 159, no.4, p. 644-651.e4 (2011) |
| سنة النشر: | 2011 |
| المجموعة: | DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| مصطلحات موضوعية: | Dimercaptosuccinic acid, VUR, C reactive protein, Procalcitonin, Succimer, Article, Cystography, Disease association, Human, Kidney parenchyma, Kidney scintiscanning, DMSA, Meta analysis, Multicenter study (topic), Predictive value, Priority journal, Protein blood level, Sensitivity and specificity, Systematic review, Urinary tract, Urinary tract infection, Vesicoureteral reflux, PCT, Calcitonin, Child, Preschool, Dilatation, Pathologic, Humans, Infant |
| الوصف: | Objective: To assess the predictive value of procalcitonin, a serum inflammatory marker, in the identification of children with first urinary tract infection (UTI) who might have high-grade (≥3) vesicoureteral reflux (VUR). Study design: We conducted a meta-analysis of individual data, including all series of children aged 1 month to 4 years with a first UTI, a procalcitonin (PCT) level measurement, cystograms, and an early dimercaptosuccinic acid scan. Results: Of the 152 relevant identified articles, 12 studies representing 526 patients (10% with VUR ≥3) were included. PCT level was associated with VUR ≥3 as a continuous (P =.001), and as a binary variable, with a 0.5 ng/mL preferred threshold (adjusted OR, 2.5; 95% CI, 1.1 to 5.4). The sensitivity of PCT ≥0.5 ng/mL was 83% (95% CI, 71 to 91) with 43% specificity rate (95% CI, 38 to 47). In the subgroup of children with a positive results on dimercaptosuccinic acid scan, PCT ≥0.5 ng/mL was also associated with high-grade VUR (adjusted OR, 4.8; 95% CI, 1.3 to 17.6). Conclusions: We confirmed that PCT is a sensitive and validated predictor strongly associated with VUR ≥3, regardless of the presence of early renal parenchymal involvement in children with a first UTI. © 2011 Mosby Inc. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0022-3476 |
| Relation: | boreal:123243; http://hdl.handle.net/2078.1/123243; urn:ISSN:0022-3476 |
| DOI: | 10.1016/j.jpeds.2011.03.008 |
| الاتاحة: | http://hdl.handle.net/2078.1/123243 https://doi.org/10.1016/j.jpeds.2011.03.008 |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.5F3CA4EE |
| قاعدة البيانات: | BASE |
| تدمد: | 00223476 |
|---|---|
| DOI: | 10.1016/j.jpeds.2011.03.008 |