Academic Journal
Correlations between capillary density and degree of skin pigmentation in healthy children analysed by nailfold video capillaroscopy
| العنوان: | Correlations between capillary density and degree of skin pigmentation in healthy children analysed by nailfold video capillaroscopy |
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| المؤلفون: | Sandy C. Bergkamp, Vanessa Smith, Taco W. Kuijpers, Maurizio Cutolo, J. Merlijn van den Berg, Dieneke Schonenberg-Meinema |
| المساهمون: | Bergkamp, Sandy C., Smith, Vanessa, Kuijpers, Taco W., Cutolo, Maurizio, Merlijn van den Berg, J., Schonenberg-Meinema, Dieneke |
| سنة النشر: | 2023 |
| المجموعة: | Università degli Studi di Genova: CINECA IRIS |
| الوصف: | Background: Nailfold video capillaroscopy (NVC) is a simple, non-invasive diagnostic tool but studies with normal values for capillary density in healthy children are rare. Ethnic background seems to play a role in capillary density; however, this is not well substantiated yet. In this work, we set out to evaluate influence of ethnic background/skin pigmentation and age on capillary density reading in healthy children. Secondary aim was to investigate whether there is a significant difference in density between different fingers within the same patient. Methods: Between 2016 and 2021, healthy children from schools around AUMC were approached, by convenience sampling. In this cross-sectional study, capillaroscopic images were obtained in a one-time videocapillaroscopy (×200 magnification) addressing the capillary density (i.e., number of capillaries per linear millimetre in the distal row). This parameter was compared to age, sex, ethnicity, skin pigment grade (I-III) and between eight different fingers, excluding the thumbs. Density differences were compared by ANOVAs. Correlations between capillary density and age were calculated with Pearson correlations. Results: We investigated 145 healthy children with mean age of 11.03 years (SD 3.51). The range of capillary density was 4–11 capillaries per millimetre. We observed a lower capillary density in the ‘grade II’ (6.4±0.5 cap/mm, P<0.001) and ‘grade III’ (5.9±0.8 cap/mm, P<0.001) pigmented-classified groups compared to the ‘grade I’ group (7.0±0.7 cap/mm). We did not find a significant correlation between age and density in the overall group. The fifth fingers on both sides had a significantly lower density compared to the other fingers. Conclusions: Healthy children <18 years with higher degree of skin pigmentation show a significantly lower nailfold capillary density. In subjects with an African/Afro-Caribbean and North-African/Middle- Eastern ethnicity, a significantly lower mean capillary density was observed compared to subjects with the Caucasian ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000990000500001; firstpage:3938; lastpage:3947; numberofpages:10; journal:QUANTITATIVE IMAGING IN MEDICINE AND SURGERY; https://hdl.handle.net/11567/1136955; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85166427032 |
| DOI: | 10.21037/qims-22-993 |
| الاتاحة: | https://hdl.handle.net/11567/1136955 https://doi.org/10.21037/qims-22-993 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5F33B56D |
| قاعدة البيانات: | BASE |
| DOI: | 10.21037/qims-22-993 |
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