التفاصيل البيبلوغرافية
| العنوان: |
Dopamine-inhibited POMCDrd2+neurons in the ARC acutely regulate feeding and body temperature |
| المؤلفون: |
Gaziano, Isabella, Corneliussen, Svenja, Biglari, Nasim, Neuhaus, Rene, Shen, Linyan, Sotelo-Hitschfeld, Tamara, Klemm, Paul, Steuernagel, Lukas, De Solis, Alain J., Chen, Weiyi, Wunderlich, F. Thomas, Kloppenburg, Peter, Bruening, Jens C. |
| بيانات النشر: |
AMER SOC CLINICAL INVESTIGATION INC |
| سنة النشر: |
2022 |
| المجموعة: |
Cologne University: KUPS |
| مصطلحات موضوعية: |
ddc:no |
| الوصف: |
Dopamine acts on neurons in the arcuate nucleus (ARC) of the hypothalamus, which controls homeostatic feeding responses. Here we demonstrate a differential enrichment of dopamine receptor 1 (Drd1) expression in food intake-promoting agouti related peptide (AgRP)/neuropeptide Y (NPY) neurons and a large proportion of Drd2-expressing anorexigenic proopiomelanocortin (POMC) neurons. Owing to the nature of these receptors, this translates into a predominant activation of AgRP/NPY neurons upon dopamine stimulation and a larger proportion of dopamine -inhibited POMC neurons. Employing intersectional targeting of Drd2-expressing POMC neurons, we reveal that dopamine-mediated POMC neuron inhibition is Drd2 dependent and that POMCDrd2+ neurons exhibit differential expression of neuropeptide signaling mediators compared with the global POMC neuron population, which manifests in enhanced somatostatin responsiveness of POMCDrd2+ neurons. Selective chemogenetic activation of POMCDrd2+ neurons uncovered their ability to acutely suppress feeding and to preserve body temperature in fasted mice. Collectively, the present study provides the molecular and functional characterization of POMCDrd2+ neurons and aids our understanding of dopamine-dependent control of homeostatic energy-regulatory neurocircuits. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
Gaziano, Isabella orcid:0000-0002-9513-5156 , Corneliussen, Svenja orcid:0000-0003-2923-0742 , Biglari, Nasim, Neuhaus, Rene orcid:0000-0002-5810-8386 , Shen, Linyan, Sotelo-Hitschfeld, Tamara, Klemm, Paul orcid:0000-0002-5985-1737 , Steuernagel, Lukas orcid:0000-0003-0043-1436 , De Solis, Alain J., Chen, Weiyi, Wunderlich, F. Thomas, Kloppenburg, Peter and Bruening, Jens C. (2022). Dopamine-inhibited POMCDrd2+neurons in the ARC acutely regulate feeding and body temperature. JCI Insight, 7 (21). ANN ARBOR: AMER SOC CLINICAL INVESTIGATION INC. ISSN 2379-3708 |
| الاتاحة: |
https://kups.ub.uni-koeln.de/66966/ |
| رقم الانضمام: |
edsbas.5F1FB25 |
| قاعدة البيانات: |
BASE |