Academic Journal
Low plateletpoor plasma concentrations of serotonin in patients with combat-related posttraumatic stress disorder
| العنوان: | Low plateletpoor plasma concentrations of serotonin in patients with combat-related posttraumatic stress disorder |
|---|---|
| المؤلفون: | Baruch Spivak, Yaffa Vered, Eran Graff, Ilana Blum, Roberto Mester, Abraham Weizman |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://homepage.psy.utexas.edu/homepage/faculty/Salinas/PTSD.BioPsychia/23Low5HT.pdf. |
| سنة النشر: | 1999 |
| المجموعة: | CiteSeerX |
| مصطلحات موضوعية: | Key Words, Posttraumatic stress disorder, serotonin |
| الوصف: | Background: Combat-related posttraumatic stress disorder (CR-PTSD) is associated with a dysregulation of various neurotransmitter systems. Methods: We assessed levels of platelet-poor plasma (PPP) norepinephrine (NE), and serotonin (5-HT), and 24-hour urinary excretion of NE, dopamine (DA), and homovanillic acid (HVA) in 17 male outpatients with untreated chronic CR-PTSD (age, 33.1 � 7.4 years) and 10 normal control subjects (age, 35.8 � 2.7 years). Results: Compared with the control subjects, the PTSD patients showed significantly lower PPP 5-HT levels, elevated PPP NE levels, and significantly higher mean 24-hour urinary excretion of all three catecholamines (NE, DA, and HVA). The 24-hour urinary HVA values of the CR-PTSD patients correlated significantly and positively with the total Impact of Event Scale scores and the avoidance symptoms cluster scores, and the PPP 5-HT levels correlated negatively with the Hamilton Anxiety Rating Scale scores. The PPP NE/5-HT ratio was significantly higher in the study group than in the control subjects. Conclusions: We believe this combined enhanced noradrenergic activity and diminished 5-HT activity may be relevant to the neurobiology of CR-PTSD. Biol Psychiatry |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.421.3775; http://homepage.psy.utexas.edu/homepage/faculty/Salinas/PTSD.BioPsychia/23Low5HT.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.421.3775 http://homepage.psy.utexas.edu/homepage/faculty/Salinas/PTSD.BioPsychia/23Low5HT.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.5F1CFFB3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |