التفاصيل البيبلوغرافية
| العنوان: |
The binary and ternary amorphous systems of candesartan cilexetil preparation to improve its solubility |
| المؤلفون: |
Alatas, Fikri |
| المصدر: |
International Journal of Applied Pharmaceutics; Articles In Press [Sep-Oct 2024] ; 0975-7058 |
| بيانات النشر: |
Innovare Academic Sciences Pvt. Ltd. |
| سنة النشر: |
2024 |
| المجموعة: |
Innovare Academic Sciences: E-Journals |
| مصطلحات موضوعية: |
Candesartan cilexetil, l-Arginine, Polyvinylpyrrolidone K25, Amorphous, Solubility |
| الوصف: |
Objective: The objectives of this work was to prepare the binary and ternary amorphous systems of candesartan cilextil, characterize these, and evaluate their influence on solubility. Methods: Candesartan cilexetil was prepared in three amorphous systems, namely candesartan cilexetil-l-arginine binary co-amorphous system (CAN-ARG CAMS), binary solid dispersion of candesartan cilexetil with 10, 20, and 30% of polyvinylpyrrolidone K25 (CAN-PVP K25 ASD), and ternary co-amorphous system candesartan cilexetil-l-arginine with 10, 20, and 30% of polyvinylpyrrolidone K25 (CAN-ARG-PVP K25 CAMS). All amorphous systems were characterized by polarizing microscopy and differential scanning calorimetry (DSC) methods, while the degree of crystallinity was calculated based on powder X-ray diffraction (PXRD) patterns. The solubility test of all amorphous systems of candesartan cilexetil was carried out respectively in water solvent (25±0.5°C) and phosphate buffer solution with a pH of 6.5 that contained 0.70% polysorbate 20 at 37±0.5°C. Results: The utilization of polarizing microscopy, DSC, and PXRD methods revealed that not all candesartan cilexetil present in the CAN-ARG binary CAMS and CAN-PVP K25 binary ASD transformed into the amorphous form. Nevertheless, in the context of CAN-ARGPVP K25 ternary CAMS, it was seen that the entirety of the candesartan cilexetil transformed from crystalline into amorphous form. The solubility of candesartan cilexetil in water and a pH 6.5 buffer solution was improved by all amorphous systems. The CAN-ARG-PVP K25 ternary CAMS exhibited higher solubility than the two binary amorphous systems. Conclusion: it can be inferred that the synthesis of binary and ternary amorphous candesartan cilexetil has yielded positive outcomes, resulting in an enhanced solubility of this API. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://journals.innovareacademics.in/index.php/ijap/article/view/51141 |
| الاتاحة: |
https://journals.innovareacademics.in/index.php/ijap/article/view/51141 |
| Rights: |
Copyright (c) 2024 Fikri Alatas ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: |
edsbas.5F039397 |
| قاعدة البيانات: |
BASE |