التفاصيل البيبلوغرافية
| العنوان: |
Does the term 'trophic' actually mean anti-amyloidogenic? The case of NGF. |
| المؤلفون: |
CALISSANO, PIETRO, Amadoro, G, Matrone, C, Ciafrè, S, Marolda, R, Corsetti, V, Ciotti, MT, Mercanti, D, Di Luzio, A, Severini, C, Provenzano, C, CANU, NADIA |
| المساهمون: |
Calissano, P, Amadoro, G, Matrone, C, Ciafrè, S, Marolda, R, Corsetti, V, Ciotti, M, Mercanti, D, Di Luzio, A, Severini, C, Provenzano, C, Canu, N |
| بيانات النشر: |
Nature Publishing Group |
| سنة النشر: |
2010 |
| المجموعة: |
Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: |
NGF, apoptosis, APP, amyloid, Settore BIO/09 - FISIOLOGIA |
| الوصف: |
The term trophic is widely used to indicate a general pro-survival action exerted on target cells by different classes of extracellular messengers, including neurotrophins (NTs), a family of low-molecular-weight proteins whose archetypal member is the nerve growth factor (NGF). The pro-survival action exerted by NTs results from a coordinated activation of multiple metabolic pathways, some of which have only recently come to light. NGF has been shown to exert a number of different, experimentally distinguishable effects on neurons, such as survival, differentiation of target neurons, growth of nerve fibers and their guidance (tropism) toward the source of its production. We have proposed a more complete definition of the NGF trophic action that should also include its newly discovered property of inhibiting the amyloidogenic processing of amyloid precursor protein (APP), which is among the first hypothesized primary trigger of Alzheimer's disease (AD) pathogenesis. This inhibitory action appears to be mediated by a complex series of molecular events and by interactions among NGF receptors (TrkA and p75), APP processing and tau metabolic fate and func |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/20395961; info:eu-repo/semantics/altIdentifier/wos/WOS:000278726100007; volume:17; issue:7; firstpage:1126; lastpage:1133; numberofpages:8; journal:CELL DEATH AND DIFFERENTIATION; http://hdl.handle.net/2108/56792; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-77953619382 |
| الاتاحة: |
http://hdl.handle.net/2108/56792 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.5EFCB7C6 |
| قاعدة البيانات: |
BASE |