Academic Journal
Excesive consumption of unsaturated fatty acids leads to oxidative and inflammatory instability in Wistar rats
| العنوان: | Excesive consumption of unsaturated fatty acids leads to oxidative and inflammatory instability in Wistar rats |
|---|---|
| المؤلفون: | Grujić-Milanović, Jelica, Miloradović, Zoran, Mihailović-Stanojević, Nevena, Banjac, Vojislav V., Vidosavljević, Strahinja, Ivanov, Milan, Karanović, Danijela, Vajić, Una Jovana, Jovović, Đurđica |
| المصدر: | Biomedicine & Pharmacotherapy |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Dysfunctional HDL-C, High fat diet, IL-6, Myeloperoxidase, Pentraxin-3, Soybean oil |
| الوصف: | Lifestyle modifications such as increase in high-fat food consumption importantly increases the risks for cardiovascular disease. The principal objective of this study is to analyze effects of different high fat diet (HFD) sources on haemodynamic parameters, lipid and oxidative profile, myeloperoxidase activity, and markers of inflammation (IL-6/pentraxin-3). HFD containing 20% of fat, provided by lard (saturated) or soybean oil (unsaturated), as well as control diet were administering to three groups (L, SO and C). Food efficiency ratio and plasma lipids were significantly elevated in both HFD groups. However, only SO group showed an increase in systolic arterial pressure, oxidative stress index, myeloperoxidase activity, liver lipids as well as markers of inflammation: IL-6 and pentraxin-3 (PTX3). In summary, these results indicate inflammogenic potential of excessive soybean oil consumption in triggering liver damage. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0753-3322 |
| Relation: | info:eu-repo/grantAgreement/MESTD/inst-2020/200015/RS//; Serbia-Croatia Bilateral agreement (No. 337-00-205/2019-09/32); http://rimi.imi.bg.ac.rs/handle/123456789/1132; http://rimi.imi.bg.ac.rs/bitstream/id/2422/Excesive_consumption_2021.pdf; 000663679300002 |
| DOI: | 10.1016/j.biopha.2021.111691 |
| الاتاحة: | http://rimi.imi.bg.ac.rs/handle/123456789/1132 https://doi.org/10.1016/j.biopha.2021.111691 http://rimi.imi.bg.ac.rs/bitstream/id/2422/Excesive_consumption_2021.pdf |
| Rights: | openAccess ; https://creativecommons.org/licenses/by-nc-nd/4.0/ ; BY-NC-ND |
| رقم الانضمام: | edsbas.5E9E319C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 07533322 |
|---|---|
| DOI: | 10.1016/j.biopha.2021.111691 |