Academic Journal

Variability in the Response against Teladorsagia circumcincta in Lambs of Two Canarian Sheep Breeds

التفاصيل البيبلوغرافية
العنوان: Variability in the Response against Teladorsagia circumcincta in Lambs of Two Canarian Sheep Breeds
المؤلفون: Tara Pérez-Hernández, Julia N. Hernández, Cynthia Machín, Tom N. McNeilly, Alasdair J. Nisbet, Jacqueline B. Matthews, Stewart T. G. Burgess, Jorge F. González
المصدر: International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 29
بيانات النشر: Multidisciplinary Digital Publishing Institute
سنة النشر: 2022
المجموعة: MDPI Open Access Publishing
مصطلحات موضوعية: gastrointestinal nematodes, genetic resistance, sheep, immunology, transcriptomic analysis
جغرافية الموضوع: agris
الوصف: The increasing resistance to anthelmintics has necessitated the exploration of alternative control strategies of gastrointestinal nematode (GIN) infections. A sustainable option is genetic selection based on differences in susceptibility to GIN infection between and within breeds of sheep. Here, three-month-old Canaria Hair breed (GIN-resistant) and Canaria Sheep breed (GIN-susceptible) showed no significant between-breed differences after trickle infection with Teladorsagia circumcincta, whereas considerable individual variability was found in both breeds. Next, data from lambs of both breeds were used to explore the relationships between parasitological variables and T. circumcincta-specific IgA levels, local immune cell populations, and abomasal lymph node gene expression to understand the possible mechanisms underlying resistance. Mucosal IgA levels as well as numbers of globular leukocytes and MHC-II+ cells were associated with protection. Analysis of lymph node gene expression revealed the associations between lower parasite numbers and cumulative fecal egg counts and several immune pathways, such as leukocyte cell adhesion, activation and differentiation of T cells, in particular CD4+ and IL-4 production. The data obtained here may inform on the relationship between phenotypic resistance variability and protective responses at the humoral, cellular, and transcriptomic levels, thus contributing to identifying immune responses in young lambs that could be used as markers for selection.
نوع الوثيقة: text
وصف الملف: application/pdf
اللغة: English
Relation: Molecular Biology; https://dx.doi.org/10.3390/ijms24010029
DOI: 10.3390/ijms24010029
الاتاحة: https://doi.org/10.3390/ijms24010029
Rights: https://creativecommons.org/licenses/by/4.0/
رقم الانضمام: edsbas.5E8EB1E8
قاعدة البيانات: BASE