Academic Journal
Sepsis-induced changes in differentiation, maintenance, and function of memory CD8 T cell subsets
| العنوان: | Sepsis-induced changes in differentiation, maintenance, and function of memory CD8 T cell subsets |
|---|---|
| المؤلفون: | Mohammad Heidarian, Thomas S. Griffith, Vladimir P. Badovinac |
| المصدر: | Frontiers in Immunology, Vol 14 (2023) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | sepsis, memory, CD8 T cell, composition, differentiation, function, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Formation of long-lasting memory lymphocytes is one of the foundational characteristics of adaptive immunity and the basis of many vaccination strategies. Following the rapid expansion and contraction of effector CD8 T cells, the surviving antigen (Ag)-specific cells give rise to the memory CD8 T cells that persist for a long time and are phenotypically and functionally distinct from their naïve counterparts. Significant heterogeneity exists within the memory CD8 T cell pool, as different subsets display distinct tissue localization preferences, cytotoxic ability, and proliferative capacity, but all memory CD8 T cells are equipped to mount an enhanced immune response upon Ag re-encounter. Memory CD8 T cells demonstrate numerical stability under homeostatic conditions, but sepsis causes a significant decline in the number of memory CD8 T cells and diminishes their Ag-dependent and -independent functions. Sepsis also rewires the transcriptional profile of memory CD8 T cells, which profoundly impacts memory CD8 T cell differentiation and, ultimately, the protective capacity of memory CD8 T cells upon subsequent stimulation. This review delves into different aspects of memory CD8 T cell subsets as well as the immediate and long-term impact of sepsis on memory CD8 T cell biology. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1664-3224 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1130009/full; https://doaj.org/toc/1664-3224; https://doaj.org/article/208c71015a734de9a03c59b9a4824f7d |
| DOI: | 10.3389/fimmu.2023.1130009 |
| الاتاحة: | https://doi.org/10.3389/fimmu.2023.1130009 https://doaj.org/article/208c71015a734de9a03c59b9a4824f7d |
| رقم الانضمام: | edsbas.5E878573 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16643224 |
|---|---|
| DOI: | 10.3389/fimmu.2023.1130009 |