Academic Journal
Therapeutic role of methotrexate in pediatric Crohn’s disease
| العنوان: | Therapeutic role of methotrexate in pediatric Crohn’s disease |
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| المؤلفون: | Zlatko Djurić, Ljiljana Šaranac, Ivana Budić, Voja Pavlović, Jelena Djordjević |
| المصدر: | Biomolecules & Biomedicine, Vol 18, Iss 3 (2018) |
| بيانات النشر: | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| سنة النشر: | 2018 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Methotrexate, Crohn’s disease, children, therapy, MTX, thiopurines, Biology (General), QH301-705.5 |
| الوصف: | The main role of therapy in Crohn’s disease (CD) is to achieve long-term clinical remission, and to allow for normal growth and development of children. The immunomodulatory drugs used for the maintenance of remission in CD include thiopurines (azathioprine and 6-mercaptopurine) and methotrexate (MTX). Development of hepatosplenic T-cell lymphoma in some patients with inflammatory bowel disease, treated with thiopurines only or in combination with anti-tumor necrosis factor agents, resulted in a growing interest in the therapeutic application of MTX in children suffering from CD. This review summarizes the literature on the therapeutic role of MTX in children with CD. MTX is often administered as a second-line immunomodulator, and 1-year clinical remission was reported in 25–69% of children with CD after excluding for the use of thiopurines. Initial data on MTX effectiveness in mucosal healing, and as a first-line immunomodulator in pediatric patients with CD, are promising. A definite conclusion, however, may only be made on the basis of additional research with a larger number of subjects. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2831-0896 2831-090X |
| Relation: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/2792; https://doaj.org/toc/2831-0896; https://doaj.org/toc/2831-090X; https://doaj.org/article/d0cfa33466274cbf920bc28275c313e2 |
| DOI: | 10.17305/bjbms.2018.2792 |
| الاتاحة: | https://doi.org/10.17305/bjbms.2018.2792 https://doaj.org/article/d0cfa33466274cbf920bc28275c313e2 |
| رقم الانضمام: | edsbas.5E6C9A1A |
| قاعدة البيانات: | BASE |
| تدمد: | 28310896 2831090X |
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| DOI: | 10.17305/bjbms.2018.2792 |